JNNP: Myelin less protrusion glial cell glycoprotein antibody-related diseases, optic neurospinal cord disease spectrum disorders in the brain thymus and cer cerebral injury comparison

MoGAD is an inflammatory demyelination disease defined as MOG IgG serum-positive, unlike multiple sclerosis (MS) and water channel protein-4-IgG serotonin-positive visual neurospinalitis spectrum disorder (AQP4 IgG NMOSD).
moGAD, common brain and small brain injuries, clinical syndrome can be very serious.
, however, data on MOGAD brain thyrs and small brain injuries are limited to a subset of case series that include all affected regions.
lack of a direct comparison of MOGAD brain and cer cerebral injury with optic neuroscolons spectrum disorders and MS, it is important to distinguish MOGAD from these diseases due to differences in treatment and prognosis.
involvement in MOGAD with the characteristics of the brain and brain will enable clinicians to better identify patients suitable for MOG-IgG serological testing.
this is particularly important because sorting at low probability situations may increase the risk of false positives.
study, we attempted to determine the frequency, associated symptoms and signs of cerebral and cer cerebral injury in MOGAD, laboratory and MRI characteristics, and their differences from AQP4 IgG NMOSD and MS.
retrospective analysis of 185 patients with MOGAD in Mayo clinic: analysis of characteristic MOGAD esotypes, all patients were evaluated for MOG-IgG1 serotypes using live cell-based analysis methods.
(3) the brain, the small brain, or both MRI lesions.
compared symptomatic seizures with AQP4 IgG NMOSD (n=30) and MS (n=30).
data were collected from each patient's first brain or small brain attack, so patients with multiple brain dry or small brain attacks were evaluated only at the first seizure.
is defined as brain MRI lesions associated with symptoms or signs of cerebral thym,dwelling, the small brain, or both dysfunction within 30 days.
collected by the United States include age of onset, sex, race, and recent vaccinations.
assessed whether symptoms were isolated from the brain trunk or brain, as well as clinical characteristics, including vision caused by CN III, IV, or VI paralysis, nucleocardial paralysis, facial numbness, CNVII paralysis, including hearing loss and dizziness, difficulty swallowing, stubborn nausea or vomiting, comorbidity disorders, ophthalmological myoclonus, and trigembling nerve pain.
reviewed the results of the cerebrospinal fluid (CSF) test.
all available MRI sequences were reviewed.
185 MOGAD patients, 62 (34%) suffered from brain or small brain injury, including 39 (63%) of those with symptoms.
disorders (45%) and resocal (26%) are common manifestations.
the median age (range) of
MOGAD patients was 24 years (2-65 years), lower than MS patients 36 years old (16-65 years old, p-0.046), and AQP4-IgG-NMOSD patients were 45 years old (6-72 years old, p-0.006).
in patients with MOGAD, the risk of isolated seizures (9/39 (23%) was lower than in patients with MS (22/30 (73%)
;p .lt;001), but there was no significant difference with patients with AQP4 IgG NMOSD (14/30 (47%) ;p =0.07).
diffuse cer cerebral foot MRI lesions are beneficial to MOGAD (17/37 (46%), higher than MS (3/30 (10%) ;p s 0.001) and AQP4 IgG NMOSD (3/30 (10%) ;p s 0.001).
diffuse myelin, brain bridge, or mid-brain MRI lesions occur sped up in MOGAD and AQP4 IgG NMOSD, but never in MS.
cerebrospinal fluid (CSF) oligoclonal bands are rare in MOGAD (5/30 (17%) and AQP4 IgG NMOSD (2/22 (9%) ;p-0.68), but are common in MS (18/22 (82%) ;p-lt;0.001).
differences between the two groups in terms of minimum or recovery period.
is common in MOGAD for cerebral thym, neural, or both, but usually occurs as an integral part of a multisteble central nervous system attack rather than in isolation.
the clinical characteristics analyzed in this article help distinguish MOGAD from AQP4 IgG NMOS and MSBanks SA, Morris PP, Chen JJ, et al Brainstem and cerebellar involvement in MOG-IgG-associated disorder versus aquaporin-4-IgG and MSJour of Neurology, Neurosurgery and Psimology Published Online First: 28 December 2020. doi: 10.1136/jnnp-2020-325121MedSci Original Source: MedSci Original Copyright Notice: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, pictures and audio and video materials, Copyright is owned by Metz Medicine and may not be reproduced by any media, website or individual without authorization, with the following "Source: Metz Medicine" stated at the time of reprint.
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