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    Home > Active Ingredient News > Study of Nervous System > JNNP: Neuroinflammation predicts disease progression in progressive supranuclear palsy

    JNNP: Neuroinflammation predicts disease progression in progressive supranuclear palsy

    • Last Update: 2021-04-13
    • Source: Internet
    • Author: User
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    In progressive supranuclear palsy (PSP) and other diseases such as Alzheimer's disease (AD) and frontotemporal dementia, as well as genetic, epidemiological and imaging associations, neuroinflammation is considered to be a common cause of disease process.


    Positron emission tomography (PET) has been used clinically to assess neuroinflammation and tau pathological accumulation in clinical cohorts in the body.


    PCs for gray matter volume, inflammation and tau pathology.


    According to the 1996 standards of the Movement Disorder Society (MDS), 17 patients with clinically diagnosed PSP were recruited .


    diagnosis

    For each subject, the dynamic PET image sequence of each scan is strictly consistent with the T1-weighted MRI image.


    The PCA component that reflects brainstem and cerebellar nerve inflammation and tau load is related to the subsequent annual rate of change of pspr.


    The clinical severity measured by PSPRS.


    In view of previous reports on the utility of assessing visual and volume atrophy in the midbrain and other subcortical regions (including caudate nucleus, putamen, globus pallidus, subthalamus, and thalamus) as biomarkers in PSP patients, structural MRI predictive values ​​are invalid The results may be surprising.


    Immunization MalpettiM ,PassamontiL ,JonesPS MalpettiM Malpetti PassamontiL Passamonti JonesPS Jones , et al bmj.
    com/content/early/2021/03/17/jnnp-2020-325549" target="_blank" rel="noopener">Neuroinflammation predicts disease progression in progressive supranuclear palsy Journal of Neurology, Neurosurgery & Psychiatry  Published Online First:  17 March 2021.
      Published Online First: doi:  10.
    1136/jnnp-2020-325549 doi: leave a message here
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