JNNP: Risk Score for Middle-aged and Alzheimer's Disease and Ageing Awareness: A Population-Based Twin Study That Followed For More Than 20 Years

Dementia is a major challenge for health care and society.
currently has a treatment similar to Alzheimer's disease (AD).
, however, multi-sphere lifestyle interventions may delay the onset of dementia.
early detection of high-risk groups may help target multi-sphere lifestyle interventions and to find disease treatment drugs for preclinical AD, as the AD process begins 20-30 years before diagnosis.
risk score can predict Alzheimer's disease, but very few middle-aged dementia risk scores exist.
risk scores can predict cognitive impairment, but it is not clear whether these associations are significant when controlling for common genetic and environmental factors.
, based on cardiovascular risk factors, aging and dementia (CAIDE), the authors looked at whether middle-aged twins with a higher risk of dementia had poor cognitive abilities compared to lower-risk identical twins.
method: Using a two-queue study based on finnish older persons, the geriatric cognition was measured using a middle-aged questionnaire (n-15,169, with an average age of 52.0 years, with a standard deviation of 11.8) and telephone interviews (average age 74.1, standard deviation 4.1, n-4302).
linear regression analysis between and within the home.
results: In the inter-family analysis (N-2359), the higher the cognitive difference (B-0.76, 95% ci0.69-0.83), the higher the CAIDE score, the worse the cognitive difference (B-0.73, 95% CI-0.82-0.65).
in double-egg (DZ) pairs (B=0.78,95% CI 0.25-1.31; N=338), there was a significant correlation between in-twin differences in educational career scores and cognitive differences in twins (MZ) (B=0.12, 95% CI=0.44-0.68; N=221).
difference in the twin-to-inner CADE score is independent of the difference in the twin-to-internal cognition: DZ B=0.38 (95%CI=0.90-0.14, N=343) and MZ B=0.05 (95% CI=0.59-0.49; N=226).
conclusion: Middle-aged dementia risk scores predict cognitive function in older adults, but correlations within the twin group rarely support associations independent of common environments and genetic factors.
understanding the genetic basis of the risk score-cognitive association is important for early detection of dementia and design of intervention trials.
online: 20-year dementia risk prediction (CAIDE score) for middle-year-olds