JNNP: Summarizing more than 200 studies, what are the performance of the main central system of the new crown?

A growing body of evidence shows the neurological and neuropsychiatric characteristics of SARS-CoV-2 infection
.
In this systematic review and meta-analysis, Jonathan P Rogers of UCL and others systematically described the characteristics of the early literature and the prevalence of neurological and neuropsychological manifestations

They searched for randomized controlled trials, cohort studies, case-control studies, cross-sectional studies, and case series as of July 18, 2020 in MEDLINE, Embase, PsycINFO and CINAHL
.
Studies reporting the prevalence of neurological or neuropsychiatric symptoms are combined into a meta-analysis to estimate the collective prevalence

They identified 215 included studies, including 37 cohort studies, 15 case-control studies, 80 cross-sectional studies, and 83 case series from 30 countries
.
147 studies were included in the meta-analysis

Symptoms with the highest prevalence are anosmia (43.

Mental symptoms mainly include: depression (23.
0% (95% CI 11.
8% to 40.
2%), n=43 128, 10 studies), headache (20.
7% (95% CI 16.
1% to 26.
1%), n=64 613, 84 studies), anxiety (15.
9% (5.
6% to 37.
7%), n=42 566, 9 studies) and mental status changes (8.
2% (95% CI 4.
4% to 14.
8%), n =49 326, 19 studies)
.

Most clinical manifestations are highly heterogeneous
.

The results of this meta-analysis show that in the early stages of the pandemic, the neurological and neuropsychiatric symptoms of COVID-19 are diverse and common
.
The neurology and psychiatric academic community should establish systems that promote high-quality methods, including more rapid examination of the longitudinal processes of neuropsychiatric complications of emerging diseases and their relationship with neuroimaging and inflammatory biomarkers