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Parkinson's disease (PD) is the second leading neurodegenerative disease after Alzheimer's disease
.
In 2016, an estimated 6.
prevention
The incidence of PD in males is 1.
4 times higher than in females
The mortality rate of PD patients is higher than that of non-PD patients
.
However, in the general population, whether developing early in life and being identified as a significant predictor of mortality throughout life would confer a different risk of death in patients with PD and those without PD is unclear
With this, Merete Oslera et al in Denmark included 656,751 males born in 1939-1959 who tracked PD and mortality in Danish registries from 1977-2018, and this information was obtained from conscription examinations around the age of 19
.
Cox proportional hazards regression was used for analysis
During follow-up, 5264 (0.
8%) men were diagnosed with PD
Diagnosed higher intelligence, education, and physical height confer a higher risk of PD, independent of age at onset
Intelligence was inversely associated with mortality in men with and without PD
.
Higher education and physical height were also inversely associated with mortality in men without peritonitis, while estimates for men with peritonitis were less pronounced and imprecise
Obese BMI is associated with higher mortality in men with PD
.
The significance of the study is that it found that intelligence, education, and physical height at a young age were positively associated with men's later risk of PD
.
Higher-than-average BMI conferred only a higher risk of advanced PD
Intelligence, education, and physical height at a young age are positively associated with later PD risk in men
Original source: Osler M, Okholm GT, Villumsen M, Rozing MP, Jørgensen TSH.
Associations of Young Adult Intelligence, Education, Height, and Body Mass Index with Subsequent Risk of Parkinson's Disease and Survival: A Danish Cohort Study.
_JPD_.
Published online February 9, 2022:1-9.
doi:[10.
3233/JPD-213102](https://doi.
org/10.
3233/JPD-213102)Associations of Young Adult Intelligence, Education, Height, and Body Mass Index with Subsequent Risk of Parkinson's Disease and Survival: A Danish Cohort Study.
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