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    Home > Active Ingredient News > Study of Nervous System > JPD: Levodopa-carbidopa intestinal gel for Parkinson's disease, quality of life and symptoms?

    JPD: Levodopa-carbidopa intestinal gel for Parkinson's disease, quality of life and symptoms?

    • Last Update: 2022-02-19
    • Source: Internet
    • Author: User
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    Levodopa is the gold standard for the treatment of Parkinson's disease (PD), but it has a short plasma half-life and may cause motor fluctuations and dyskinesias
    .


    One way to address the short half-life of levodopa in patients with advanced Parkinson's disease is to develop levodopa-carbidopa enteric gel (LCIG) for continuous infusion of levodopa


    Quality of Life

    Several studies have shown that motor symptoms and dyskinesia have a large impact on HRQoL
    .


    However, results from other studies showed no or only weak associations, and some were limited by method and statistics .


    statistics


    DUOdopa/Duopa in Patients with Advanced Parkinson's Disease -- the GLobal OBservational Study to Assess Long-Term Efficacy (DUOGLO BE) -- is an ongoing long-term efficacy study of LCIG in practice
    .


    While the study is still ongoing, results from a second interim analysis of LCIG's safety and efficacy have been published



    From this, Norbert Kovacsa et al.
    , dUniversity of Pecs, explored the relationship between HRQoL and measures of PD severity and treatment effect, including motor and non-motor symptoms
    .

    A total of 195 patients were included
    .


    At baseline, HRQoL was moderately positively correlated with activities of daily living (UPDRS II, PCC=0.


    Improvements in HRQoL after 12 months of treatment with LCIG were moderately positively correlated with improvements in non-motor symptoms (PCC=0.
    42), sleep (0.
    54), and daytime sleepiness (0.
    40), and with improvements in dyskinesia symptoms and signs.
    Weak correlation (PCC=0.
    23; P=0.
    011)
    .

    Improvements in HRQoL were not associated with improvements in OFF time or dyskinesia time
    .

    The significance of the study is that it found that HRQoL was associated with both baseline and baseline changes in dyskinesia, activities of daily living, and non-motor symptoms (including sleep), both at baseline and at 12 months ; but not with baseline or OFF Changes in time are irrelevant
    .

    HRQoL was associated with both baseline and baseline changes in dyskinesia, activities of daily living, and non-motor symptoms (including sleep), both at baseline and at 12 months


    Original source:
    Kovacs N, Bergmann L, Anca-Herschkovitsch M, et al.


    Outcomes Impacting Quality of Life in Advanced Parkinson's Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel.
    .


    Outcomes Impacting Quality of Life in Advanced Parkinson's Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel.
    .
    Outcomes Impacting Quality of Life in Advanced Parkinson's Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel.
    .
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