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    Home > Active Ingredient News > Antitumor Therapy > JPM points to KRAS and p53 mutations driving cancer, new TCR cell therapy debuts

    JPM points to KRAS and p53 mutations driving cancer, new TCR cell therapy debuts

    • Last Update: 2022-01-24
    • Source: Internet
    • Author: User
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    ▎WuXi AppTec Content Team Editor A few days ago, Affini-T, a cutting-edge company that debuted at the JPM conference, introduced its innovative cell therapy technology platform and R&D pipeline
    .

    Affini-T was co-founded by scientists at the Fred Hutchinson Cancer Center in the United States to use synthetic biology and gene editing to develop a new generation of T cell receptor (TCR) cell therapies targeting cancer driver mutations
    .

    The company's R&D strategy is to target cancers driven by mutations in specific oncogenes, such as those driven by mutations in the KRAS gene, to discover specific TCRs already present in humans
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    These TCRs are able to discriminate between KRAS mutants and wild-type KRAS, providing selectivity for TCR cell therapy
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    ▲The company has discovered selective TCRs for KRAS G12V and KRAS G12D (Image source: Affini-T's official website) Affini-T's cell therapy design not only expresses TCR targeting oncogenic mutation targets in CD4-positive and CD8-positive T cells TCR, but also expresses a CD8 co-receptor
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    The CD8 co-receptor enhances TCR binding to its target
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    CD4-positive T cells expressing TCR and CD8 co-receptors can not only produce cytotoxic responses to tumor cells, but also enhance the function of CD8-positive T cells
    .

    In addition, CD4-positive T cells can also interact with dendritic cells to stimulate the secretion of IL-12, induce the production of inflammatory signals, and stimulate more anticancer immune cell responses
    .

    Image source: Affini-T's official website In order to improve the survival and function of T cells in the tumor microenvironment (TME) with immunosuppressive functions, the company has also developed a new chimeric receptor called switch
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    For example, a switch receptor replaces the intracellular domain of the Fas receptor, which originally mediates cell death signals, with 4-1BB, which promotes cell survival, so that the signal that originally caused T cell death instead promotes cell survival.
    In pancreatic cancer models has been shown to significantly prolong animal survival
    .

    Image source: Affini-T's official website The company's R&D pipeline includes candidate TCR cell therapies targeting KRAS G12V and KRAS G12D mutants, as well as p53 mutants
    .

    Investigational therapies for virus-driven cancers are already in clinical development
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    The company says its goal is to use cutting-edge engineering and synthetic biology tools to optimize T-cell function and rewrite the rules of the solid tumor microenvironment to bring lasting clinical remissions to patients
    .

    Reference: [1] Unlocking the power of T cells against oncogenic driver mutations.
    Retrieved January 14, 2022, from https:// Deck-2022-Sent.
    pdf[2] New Cell Therapy Player Makes Public Debut at JPM.
    Retrieved January 14, 2022, from https:// -makes-public-debut-at-jp-morgan-healthcare-conference/Disclaimer: The WuXi AppTec content team focuses on introducing global biomedical health research progress
    .

    This article is for information exchange purposes only, and the views expressed in this article do not represent WuXi AppTec's position, nor do they represent WuXi AppTec's support or opposition to the views expressed in this article
    .

    This article is also not a treatment plan recommendation
    .

    For guidance on treatment options, please visit a regular hospital
    .

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