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    Home > Food News > Food Articles > Key candidate genes for the development of pig cloned embryos have been found

    Key candidate genes for the development of pig cloned embryos have been found

    • Last Update: 2021-01-23
    • Source: Internet
    • Author: User
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    Recently, the animal genetic engineering and species innovation team of the Beijing Institute of Livestock and Veterinary Research of the Chinese Academy of Agricultural Sciences found that the key candidate genes related to the initial division time of pig cell cloning embryos provide a theoretical basis for improving the development efficiency of pig cloned embryos and analyzing the mechanism of sophyte cell cloning. The findings were published online in Genes.
    The team researcher Mu Yulian introduced that pig cell cloning technology is currently the only biotechnology that can obtain complete animal individuals through somatic cell genetic material, widely used in breeding new material creation, medical model construction, pig gene function research, high-quality breeding animal breeding and endangered species preservation and other fields, has important scientific research value and application value, but the technology also exists cloning embryo development ability is low, cloning technology efficiency is low.
    the study, using pig cell cloned embryos as the subject, obtained 18,460 genes, accounting for 71% of the number of pig genome annotated genes, by sequencing RNA. The researchers obtained 3,077 differential expression genes by analyzing the differences between the early split group (the initial split time was 24 hours) and the late split group (the initial split time was 36 hours).
    analysis, it was found that differential expression genes were significantly rich in transcription and translation-related pathflows, especially for kerucleosomes and brown-surface endosome protein processing paths. Further analysis found that compared with the late division cloned embryos, the number of "supply cell memory genes" mis-expressed in the early-splitting cloned embryos was smaller, indicating that the reprogramming effect of the early-splitting cloned embryos was better than that of the late-split cloned embryos.
    research is supported by projects such as the National Natural Science Foundation of China and the basic scientific research business expenses of the Chinese Academy of Agricultural Sciences. (Source: Zhang Qingdan, China Science Journal, Fu Songchuan)
    relevant paper information:
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