Key laboratory found that deep-sea bacterial polysaccharides inhibit tumor metastasis by targeting type I collagen

On August 27 , the international academic journal Journal of Biological Chemistry published an article titled " Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I ", reporting on Sun Chaomin, Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences The research results of the research group on the deep-sea bacterial polysaccharide EPS11 by directly targeting type I collagen to inhibit the adhesion, migration and invasion of liver cancer cells, thereby inhibiting tumor cell metastasis, providing new targets and candidate precursors for the development of anti-tumor metastasis drugs.

Many natural polysaccharides have significant anti-cancer activity and have less toxic and side effects on the human body.

To this end, the research team further combined proteomics, cell thermal displacement analysis, surface plasmon resonance and other methods, and found that the direct target of EPS11 anti-tumor metastasis is type I collagen, and then combined gene expression and functional blocking technology to explain EPS11 The molecular mechanism of inhibiting tumor metastasis by targeting the type I collagen- β1 integrin signaling pathway

Dr.

EPS11 inhibits tumor cell adhesion, migration, invasion and clone formation

Various ways to determine the direct target of EPS11 as type I collagen

Ge Liu, Rui Liu, Yeqi Shan,Chaomin Sun ^* .

Link to the paper: https://