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    Home > Food News > Nutrition News > Kisspeptin: a new drug for liver disease?

    Kisspeptin: a new drug for liver disease?

    • Last Update: 2022-05-28
    • Source: Internet
    • Author: User
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    Graphic abstraction
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    Journal of Clinical Investigation (2022)
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    DOI: 10.
    1172/JCI145889

    A hormone that triggers puberty and controls fertility in humans may be developed to treat nonalcoholic fatty liver disease, according to new research from Rutgers University
    .

    The study, published in the Journal of Clinical Investigation, provides strong evidence that a modified version of the naturally occurring hormone kisspeptin can be used to treat nonalcoholic fatty liver disease (NAFLD)
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    Globally, nonalcoholic fatty liver disease is the most common chronic liver disease affecting children and adults and is associated with increases in obesity and type 2 diabetes

    .

    NAFLD is called a "silent" disease because it starts with few or no symptoms
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    It starts with the accumulation of fat in the liver, leading to what is called a "fatty liver

    .
    "
    As the condition worsens, the liver can become inflamed, leading to nonalcoholic steatohepatitis (NASH)

    .
    Liver fibrosis and cirrhosis follow, scarring and irreversible damage to the liver

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    NASH patients with cirrhosis can also develop liver cancer

    .
    Currently, there are no approved treatments for NASH

    .

    The study's lead investigator, Moshmi Bhattacharya, is an associate professor in the Department of Medicine at Rutgers University's Robert Wood Johnson School of Medicine who has spent more than 15 years studying kisspeptin's role in health and disease
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    Kisspeptin, encoded by the KISS1 gene, was discovered in Hershey, Pennsylvania

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    And named after the classic Hershey's chocolate "kiss

    .
    "
    In addition to playing a key role in pubertal development and maintaining reproductive function, kisspeptin has also been linked to appetite and sexual attraction

    .

    Bhattacharya and Andy Babwa, an associate professor of pediatrics at Rutgers University's Robert Wood Johnson School of Medicine, sponsored the study to decipher the role of kisspeptin in the liver in both healthy and obese conditions
    .
    Stephania Guzman, lead author of the study, is a doctoral student in Rutgers University's Graduate Program in Molecular Biosciences

    .
    Researchers led by Waljit Dhillo of Imperial College London, UK, also participated in the collaborative study

    The researchers fed mice a high-fat, high-sugar "Western" diet to induce obesity and NAFLD
    .
    The study showed that giving these mice kisspeptin protected them from the development of fatty liver, NASH and fibrosis

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    Kisspeptin works by binding to its receptor, a protein called KISS1R

    .
    The study also showed that when KISS1R was deleted from liver cells, kisspeptin failed to function, and mice on a Western diet developed fatty livers

    .
    These experiments revealed a strong relationship between kisspeptin and reduction of liver fat and fibrosis

    .

    The study found:

    • Kisspeptin helps reduce fat deposits in the liver, reversing more severe disease
      .

    • The mechanism of action of kisspeptin in the liver is now understood
      .

    • Changes of blood kisspeptin levels in human NAFLD patients and mouse NAFLD model
      .

    "This work demonstrates a potential therapeutic role for kisspeptin receptor signaling in NAFLD," said co-author Vinod, director of hepatology and distinguished professor of medicine at Rutgers Robert Wood Johnson Medical School K Rustgi said
    .
    It works by preventing the growth of liver fat, reducing inflammation and fibrosis

    .
    As such, it has the potential to positively impact the health and lives of millions of patients worldwide

    .
    "


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