Lancet: Data from Scotland, UK, shows that AZ Covid-19 vaccine seems not as effective as Pfizer Covid-19 vaccine

On June 14, "The Lancet" published an online communication article stating that the variant B 1.
617.
2 from India quickly became the dominant strain of SARS-CoV-2 in Scotland
.

Alpha VOC (previously known as Kent VOC, B.

The Scottish Public Health Agency conducted a cohort analysis on the sequencing data of the Scottish COVID-19 surveillance platform EAVE II from April 1, 2021 to May 28, 2021 and found that 97% of the positive cases of the S gene sequenced in Scotland were Delta Variants, and 99% of Delta variants are positive for the S gene
.

It was also found that the AZ new crown vaccine does not seem to be as effective as the Pfizer new crown vaccine.
Compared with the alpha (B.

Considering the entire population (not just hospital cases), a negative test to evaluate the effectiveness of the vaccine in preventing SARS-CoV-2 infection confirmed by RT-PCR showed that the second time compared with the unvaccinated population At a dose of at least 14 days after infection, BNT162b2 (Pfizer-BioNTech vaccine) provided very good protection: 92% (95% CI 90-93) S gene negative, 79% (75-82) S gene positive
.

However, the protective effect associated with ChAdOx1 nCoV-19 (Oxford-AstraZeneca vaccine) was significant but reduced

The S gene negative cases were 73% (95% CI 66-78), and those S gene were 60% (53-66)-positive
.

These estimates were obtained from a generalized additive logic model, which was adjusted for age, time trends when swabs were collected, and the number of previous tests using splines plus gender and deprivation

The S gene negative cases were 73% (95% CI 66-78), while those S gene 60% (53-66)-positive S gene negative cases were 73% (95% CI 66-78), and those S gene negative cases were 73% (95% CI 66-78), and those S gene negative cases were 73% (95% CI 66-78).
Because 60% (53-66)-positive limits the analysis to those who reported symptoms at the time of the test, the confidence interval associated with the reduction in sample size is wider

Compared with the alpha variant, doubling the number of hospitalizations for new crown cases does not mean that the Delta variant is more pathogenic, and its infectivity can be increased by 60%

Reference: SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness, Published: June 14, 2021 DOI: https://doi.
org/10.
1016/S0140-6736(21)01358- 1 DOI: https://doi.
org/10.
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