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Liver transplant patients may increase the risk of adverse outcomes after COVID-19 infection due to common diseases and the use of immunosuppressants, but the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on this patient group has not been fully studied.
researchers recently examined the prognosis of patients with neo-coronary pneumonia after liver transplantation.
adult liver transplant patients participated in the study, the patient was laboratory confirmed SARS-CoV-2 infection, extracted patient medical records information, the main endpoints of the study include death, hospitalization, intensive care and invasive breathing.
researchers collected data from 151 adult liver transplant recipients from 18 countries, with a medium age of 60 years and 102 men, compared with 627 patients with new coronary pneumonia who did not receive liver transplants, and a control group with a middle age of 73 years and 329 men. there was no difference between
groups in hospitalization rates (124 cases (82%)vs control group 474 (76%)) or in intensive care needs (47 (31%)vs 185 (30%)).
in patients with liver transplantation, ICU hospitalization (43 (28 percent) vs. 52 (8 percent)) and invasivity (30.20 percent) vs32 .5 percent) were higher.
28 patients (19%) died in the liver transplant group and 167 (27%) in the control group.
liver transplantation did not significantly increase the risk of death in SARS-CoV-2 patients (an absolute risk difference of 1.4%), after adjusting for age, sex, creatinine concentration, obesity, hypertension, diabetes and race.
multivariate Logistic regression analysis showed that age (risk ratio of 1.06/1 year), serum creatinine concentration (1.57 per 1 mg/dL increase) and liver cancer (18.30) were associated with death from neo-coronary pneumonia infection in liver transplanters.
that liver transplantation does not increase the risk of death in patients with neo-coronary pneumonia.
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