Lancet Gastroenterol Hepatol: Do you dare to abuse antibiotics? Can lead to a significant increase in the risk of inflammatory bowel disease!

Inflammatory bowel disease (IBD) is an idynogenic chronic intestinal disease that is clinically manifested as nausea, diarrhea, and even blood stools.
the global prevalence of IBD has been on the rise in recent years, and the ulcerative colitis (UC), which recently led japanese Prime Minister Shinzo Abe to resign as prime minister for physical reasons, is also a form of IBD.
studies have shown that the gut microbiome is rich in diversity and plays an important role in maintaining human health, affecting the occurrence and process of cancer, obesity, diabetes and other diseases.
It is known that host genetics, environmental factors and the gut microbiome all have an effect on the onset of IBD, and humans are increasingly dependent on antibiotics in disease treatment, which can disrupt and permanently alter these microorganisms, leading to an imbalance in the interaction between hosts and microorganisms.
this has led to speculation that the increased prevalence of IBD may be linked to the widespread use of antibiotics.
Recently, a team of researchers from Harvard Medical School and karolinska Medical School published new research on the effects of antibiotics on IBD in The Lancet Gastroenterology Hepatology, which found that antibiotic use increases the risk of IBD, UC, and CD by more than 70 percent, and that the more antibiotics used, the broader the antimicrobial effect and the higher the risk.
researchers screened 23,982 IBD patients over the age of 16 from the Swedish Histology Report (ESPRESSO) database, which covers comprehensive gastrointestinal pathology reporting data from 2005 to 2016, including 15,951 cases of ulcerative colitis, 7,898 cases of Ron's disease, and 133 cases of unclassified IBD.
At the same time, the researchers screened 117,827 people with matching ages, genders, and education levels as a control group, and used the Swedish Register of Prescription Drugs to count the types and cumulative amounts of antibiotics used by each patient over a period of up to one year prior to diagnosis with IBD.
, the researchers analyzed the data using conditional Logistic regression to assess the association between antibiotic therapy and IBD.
After adjusting for a number of risk factors, it was found that the increase in cumulative antibiotic use was significantly associated with the occurrence of IBD, and that people who had been on antibiotics for at least one year had an 88 percent, 74 percent, and 127 percent increased risk of being diagnosed with IBD, UC, and CD, respectively, compared to the control group that did not use antibiotics.
In addition to antibiotic use in patients with inflammatory bowel disease and in the control group, there is also frequency dependence between the type of antibiotic use and the risk of IBD, i.e. the use of one antibiotic increases the risk of IBD by 11% compared to the risk of not using antibiotics, the use of two antibiotics increases the risk of IBD by 38%, and the use of three or more antibiotics increases the risk of IBD by 55%, of which the risk of CD is higher than that of UC.
researchers also studied the correlation between antibiotic coverage and found that people who used broad-spectrum antibiotics more frequently had a higher risk of developing IBD than those who used narrow-spectrum antibiotics, and that the correlation was more pronounced in CD-related diseases.
categories of drug use, cephalosporin antibiotics increased the risk of IBD the most, by 20%.
Inflammatory bowel disease patients and control group of antibiotic coverage finally, because IBD development has genetic susceptible, so the researchers further analyzed whether genetic factors will affect the relevance of antibiotics to the disease, found that genetic factors do not change the risk of antibiotics, when the patient's siblings as a control group, patients still use antibiotics will lead to an increase in IBD risk, but slightly less than when compared to the average person.
the use of antibiotics in both inflammatory bowel disease and unaffected siblings, the study identified the potential for antibiotic use to affect gut microorganisms and increase the risk of inflammatory bowel disease.
further explains that we may need to strengthen the management of the use of antibiotics to prevent an increased risk of chronic diseases similar to IBD or associated with the gut microbiotics!