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    Home > Active Ingredient News > Infection > Academician Lancet Wang Chen and others revealed that 6.9% of the Wuhan population is positive for new crown antibodies, 82% of them are asymptomatic, 40% have neutralizing antibodies and can last for at least 9 months

    Academician Lancet Wang Chen and others revealed that 6.9% of the Wuhan population is positive for new crown antibodies, 82% of them are asymptomatic, 40% have neutralizing antibodies and can last for at least 9 months

    • Last Update: 2021-04-28
    • Source: Internet
    • Author: User
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    Due to the rapid increase in new cases of iNature, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention, and the pathogen was identified as SARS-CoV-2.

    As of now (March 17, 2021), according to real-time statistics released by Johns Hopkins University, the cumulative number of confirmed cases of new coronary pneumonia worldwide has exceeded 121 million, and the death toll has reached 2.
    67 million.

    These figures are updated every day and are expected to increase further.

    To measure the seroprevalence rate of antibodies against SARS-CoV-2 (especially neutralizing antibodies) through population-based seroepidemiological surveys is helpful to assess the proportion of people infected by the virus at a certain time.
    Helps in-depth understanding of the design of the vaccination plan.

    On March 19, 2021, Wuhan Center for Disease Control and Prevention, Chinese Academy of Medical Sciences/Peking Union Medical College, Chinese Academy of Engineering and other units cooperated.
    Wang Chen, Wang Jianwei and Yang Weizhong jointly published an online publication titled “Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study" research paper, the study was conducted in Wuhan, China in April 2020.
    Biological research on antigenicology, and two follow-up follow-ups were conducted between June 2020 and October to December 2020.

    The pan-immunoglobulin, IgM, IgA and IgG antibodies against SARS-CoV-2 nucleocapsid (N) were identified, and neutralizing antibodies were identified.

    The study found that 532 (5.
    6%) of the 9542 participants were positive for pan-immunoglobulin against SARS CoV-2, and the serologically adjusted baseline prevalence rate in the population was 6.
    92%.

    Of the 532 pan-immunoglobulin-positive participants, 437 (82.
    1%) were asymptomatic.

     During the two follow-up visits, the proportion of immunoglobulin-positive individuals with neutralizing antibodies remained stable in April.

    Based on data from 335 individuals who participated in all 3 follow-ups and were pan-immunoglobulin-positive, neutralizing antibody levels did not decrease significantly during the study period.

    However, asymptomatic individuals have lower neutralizing antibody titers than confirmed cases and symptomatic individuals.

    Although the IgG titer decreased over time, the proportion of individuals with IgG antibodies did not decrease significantly.

    In short, 6.
    92% of the cross-sectional samples of the Wuhan population produced antibodies against SARS-CoV-2, and 39.
    8% of the population seroconverted into neutralizing antibodies.

    Persistence data on humoral responses indicate that mass vaccination is needed to protect the population to prevent the epidemic from re-epidemic.

    Finally, Richard Strugnell et al.
    published a review article on "Sustained neutralising antibodies in the Wuhan population suggest durable protection against SARS-CoV-2" in Lancet, which systematically summarized the research results and pointed out the persistent neutralizing antibodies in the Wuhan population Shows that it has a long-lasting protective effect on SARS-CoV-2.

    Due to the rapid increase in new cases, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention.

    The new coronavirus infection is believed to be transmitted from animals, and the pathogen has been identified as SARS-CoV-2.

    As of January 2020, it is suspected that the initially infected patient was infected with the virus through human-to-human transmission.

    Due to the rapid increase in new cases, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention, and the pathogen was identified as SARS-CoV-2.

    As of now (March 17, 2021), according to real-time statistics released by Johns Hopkins University, the cumulative number of confirmed cases of new coronary pneumonia worldwide has exceeded 121 million, and the death toll has reached 2.
    67 million.

    These figures are updated every day and are expected to increase further.

    SARS-CoV-2 infection causes detectable humoral reactions, and the proportion of asymptomatic cases is still uncertain, and is estimated to be between 6.
    3% and 96.
    0%.

    Given that people with mild infections may not seek medical attention and asymptomatic patients are usually not screened, the prevalence of SARS-CoV-2 may be greatly underestimated based on the number of reported cases.

    Usually, the seroprevalence rate of antibodies against SARS-CoV-2 (especially neutralizing antibodies) is measured through population-based seroepidemiological surveys, which helps to assess the proportion of people infected by the virus at a certain time.
    It also helps to understand the design of the vaccination plan.

    However, in China, most studies on body fluid reactions involve a small number of healthy participants or specific populations (for example, medical staff, people living with HIV, hotel staff), but this may not be the case.

    In addition, in these investigations, the neutralizing antibody concentration measurement and the individual level immunoglobulin presence test were not performed at the same time, because the procedure needs to be completed in a biosafety level 3 facility.

    Therefore, the understanding of seroconversion to provide protective antibodies in natural SARS-CoV-2 infection is limited.

    Previous studies have shown that antibodies against SARS-CoV-2 can be maintained for at least 4 months; however, after natural infection without repeated exposure, the persistence of the humoral response to SARS-CoV-2 still needs to be further clarified.

    The study conducted a population-based longitudinal serum antigenic biological study in Wuhan, China in April 2020, and conducted two follow-up visits between June 2020 and October to December 2020.

    The pan-immunoglobulin, IgM, IgA and IgG antibodies against SARS-CoV-2 nucleocapsid (N) were identified, and neutralizing antibodies were identified.

    The study found that among the 4600 households randomly selected, 3599 households (78·2%) with 9,702 persons participated in the baseline return visit.

    9,542 individuals from 3556 families have enough samples for analysis.

    Among the 9542 participants, 532 (5·6%) were positive for pan-immunoglobulin against SARS CoV-2, and the serologically adjusted baseline prevalence in the population was 6.
    92%.

    Of the 532 pan-immunoglobulin-positive participants, 437 (82.
    1%) were asymptomatic.

     Of 532 people, 69 people (13.
    0%) were positive for IgM antibodies, of which 84 people (15.
    8%) were positive for IgG antibodies, 532 (100%) were positive for IgG, and 212 people ( 39.
    8%) were positive for neutralizing antibodies at baseline.

    During the two follow-up visits, the proportion of immunoglobulin-positive individuals with neutralizing antibodies remained stable in April.

    Based on data from 335 individuals who participated in all 3 follow-ups and were pan-immunoglobulin-positive, neutralizing antibody levels did not decrease significantly during the study period.

    However, asymptomatic individuals have lower neutralizing antibody titers than confirmed cases and symptomatic individuals.

    Although the IgG titer decreased over time, the proportion of individuals with IgG antibodies did not decrease significantly.

    In short, 6.
    92% of the cross-sectional samples of the Wuhan population produced antibodies against SARS-CoV-2, and 39.
    8% of the population seroconverted into neutralizing antibodies.

    Persistence data on humoral responses indicate that mass vaccination is needed to protect the population to prevent the epidemic from re-epidemic.

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