Lancet Infect Dis: Acute simple cystitis antibiotic treatment can be shortened

Clinical studies have found that short-term antimicrobial therapy and long-term antimicrobial therapy have the same effect on acute simple cystitis, and researchers have recently re-evaluated the treatment time of antibiotics in the guidelines for the treatment of acute non-complex cystitisthis study is a systematic review and meta-analysis, collecting relevant data as of December 31, 2019, in clinical trials of antibiotic treatment for acute non-complex female cystitisClinical responses are the primary results defined as the complete disappearance of all baseline symptoms in treatment61 randomized trials, including 20,780 patientsFor third- and fourth-generation fluoroquinolones, the clinical efficacy of the 3-day scenario was similar to that of a single-dose protocol (risk ratio of 0.99 vs 1.024), with medium quality of evidenceFor Pimexilin, the 5-day or 7-day treatment regimen is similar to the 3-day treatment, with a medium quality of evidence (5-day treatment RR: 1.041, 7-day treatment option 1.095)At the same time, for third-generation cephalosporins, amoxicillin and kraviat, there was no difference between a single dose and a three-day dosing protocol, but the evidence for this conclusion was lowFor second-generation quinolones and compound neonomine, the clinical efficacy of the single-dose protocol was less than the 3-day scenario, and the evidence quality was moderatestudies suggest that the existing treatment of the third and fourth generation synolones and pimexiin for acute simple cystitis can be shortened