Lancet infect dis: postoperative wound infection rate for preoperative skin disinfection with Orancidin is lower than iodine volt disinfection

The(SSI), whichthe surgical site, is the most common problem after surgeryAlthough several guidelines suggest that disinfectants such as chlorohexanol and iodyvolt can reduce SSI rates, the best recommendations have not yet been establishedOlanexidine may have higher bactericidal activity than other disinfectantsHowever, no randomized studies have evaluated the efficacy and safety of Orancid vs conventional disinfectantsThe purpose of this study was to assess the effect of orranzin solution and iodine volt aqueous solution on the incidence of SSI after surgeryThis study is a multi-center forward-looking, randomized, double-blind dominant trial, recruiting patients 20 years and older who are to undergo gastrointestinal and hepatobiliary pancreatic surgery, with 1:1 randomized to two groups, receiving 1.5% or 10% iodine volt aqueous solution for skin disinfectionThe main outcome is the SSI rate within 30 daysJune 10, 2018 - April 18, 2019, a total of 883 patients were assessed for inclusion, of whom 587 met the requirements, 294 were disinfected by Orancidand and 293 were disinfected by iodine voltsWithin 30 days after surgery, 19 people (7%) in the Olencidate group and 39 (13%) in the iodine volt group had SSI (poor proofing risk: -0.069, 90% CI -0.009 to -0.029; The Orancidin and iodine voltgroups each had a severe skin reaction in 5 (2%) of the groupthe overall incidence of SSI can be significantly reduced by preoperative skin disinfection using Orancidin compared with iodine voltsThis study suggests that Orancidin may helpsSI in patients who undergo cleaning surgery