Lancet: Professor Liu's team found lower limit of blood pressure management after thrombectomy and recanalization in stroke patients (ENCHANTED-2/MT study)

On October 28, the main issue of the international top journal "Lancet" magazine published online the latest results of the clinical research of Professor Liu Jianmin of Changhai Hospital of Naval Military Medical University - "Research on strengthening blood pressure lowering control after successful recanalization of mechanical thrombectomy of acute ischemic stroke" (English name ENhanced Control of Hypertension ANd ThrombEctomy Stroke StuDy, English abbreviated ENCHANTED-2/MT).

。 The study lasted 4 years, cooperated by 3 countries, 8 international functional committees intervened in the whole process, 44 stroke centers in China participated, and 821 patients were finally enrolled through 1828 screenings
.
After 2758 standardized follow-ups, 5024 neurovascular images, 16616 blood pressure records, and nearly 300,000 clinical data analysis, it was confirmed for the first time in the world that "for patients with acute large-vessel occlusive ischemic stroke, after the successful opening of blood vessels through endovascular therapy, the clinical prognosis of patients with intensive blood pressure management (<120mmHg) is worse than that of standard blood pressure management (140-180mmHg)", High-level evidence supports the management of blood pressure after mechanical embolectomy and recanalization of acute ischaemic stroke, which is expected to rewrite guidelines and guide clinical practice
.

Professor Yang Pengfei and Professor Zhang Yongwei of the Center of Cerebrovascular Diseases, Changhai Hospital of Naval Military Medical University and Professor Lili Song of The George Institute for Global Health (China) in Australia are the co-first authors of the study, and Professor Liu Jianmin and Professor Craig Anderson are the co-corresponding authors
.

The Study of Intensive Antihypertensive Therapy After Mechanical Thrombectomy for Acute Ischemic Stroke (ENCHANTED-2/MT) is a prospective, multicenter, randomized, open-label, blinded endpoint (PROBE design) clinical research project jointly initiated by Changhai Hospital and George Institute for Global Health (China), with the principal investigators (PI) being Professor Liu Jianmin of Shanghai Changhai Hospital and Professor
Craige Anderson of The George Institute for Global Health 。 The project was approved by the Stroke Prevention and Control Engineering Committee of the National Health Commission, and funded by the Shanghai Municipal Science and Technology Commission and Shanghai Shenkang Medical Development Center
.

As we all know, in recent years, endovascular embolectomy has become the gold standard therapy for acute ischemic stroke, with the advancement of technology, the vascular recanalization rate has reached more than 90%, but the overall good prognosis rate of patients is only about 50%, of which perioperative blood pressure is an important factor
affecting the prognosis of patients.
The goals and protocols for blood pressure management after embolectomy also vary, and can be said to be an important concern
in the global stroke community.
Based on this, Professor Liu Jianmin of the Cerebrovascular Disease Center of Changhai Hospital and Professor Craige Anderson, a world-renowned scholar in the field of stroke blood pressure management, jointly initiated this study to explore whether intensive antihypertensive treatment regimens are more conducive to improving the functional prognosis
of patients with large-vessel occlusive acute ischemic stroke (AIS) after successful mechanical thrombectomy and recanalization.