Lancet Rheumatology: Evidence for the association between serum urate and acute attacks in patients with gout: a secondary analysis of two randomized controlled trials

Research background :

Research background Research background :

Given that the 2017 American College of Physicians guidelines advocate symptomatic treatment rather than target serum uric acid in the treatment of gout management methods, the use of serum uric acid as a treatment target and outcome measurement method has caused controversy

Given that the 2017 American College of Physicians guidelines advocate symptomatic treatment rather than target serum uric acid in the treatment of gout management methods, the use of serum uric acid as a treatment target and outcome measurement method has caused controversy

Research Method Research Method

The researchers analyzed patient-level data from two randomized trials of uric acid-lowering therapy for gout patients conducted in Nottingham, UK and New Zealand

The researchers analyzed patient-level data from two randomized trials of uric acid-lowering therapy for gout patients conducted in Nottingham, UK and New Zealand

The primary outcome was to compare the proportion of participants who had at least one attack of gout in serum uric acid responders and non-responders, and the secondary outcome was the average number of episodes per participant per month for 12 to 24 months

Research results Research results :

From the combined individual data of the two trials, the researchers identified 343 serum uric acid responders and 245 serum uric acid non-responders

From the combined individual data of the two trials, the researchers identified 343 serum uric acid responders and 245 serum uric acid non-responders

Summary summary :

Achieving a mean serum uric acid concentration of less than 6 mg/dL is related to the absence of gout attacks in gout patients and a decrease in the number of gout attacks in the following 12 months

Achieving a mean serum uric acid concentration of less than 6 mg/dL is related to the absence of gout attacks in gout patients and a decrease in the number of gout attacks in the following 12 months

Source:

Stamp, Lisa K et al.

Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials.
The Lancet Rheumatology, Volume 0, Issue 0

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Stamp, Lisa K et Al Association or BETWEEN serum urate and Flares in people with Gout and Evidence for Surrogate Status:.
Analysis of Secondary TWO A randomized Controlled Trials of The Lancet Rheumatology, Volume 0, Issue 0

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