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For many cardiovascular risk factors, there is no further reduction at the lower end of the reduction in disease risk; this includes values considered to be within the normal range for healthy adults
.
In other words, improving some bad habits can always benefit our body
Blood vessels That is to say, improving some bad habits can always benefit our body
The Comprehensive Evaluation of the Long-Term Effects of Reducing Energy Intake (CALERIE™) was a 24-month multicenter randomized controlled trial (May 2007-November 2012) in healthy adults without obesity to assess The potential of caloric restriction (CR) to promote antiaging adaptations, including those associated with disease risk
.
218 participants (age 37.
The results showed that at 12 and 24 months, the CR group had an average 11.
9% reduction in caloric intake, not only in body weight (8.
4 kg; 7.
5 kg), fat mass (6.
1 kg; 5.
3 kg), and fat-free body mass ( 2.
20 kg; 2.
17 kg), and cardiovascular disease risk markers, lipoprotein B, and GlycA, the inflammatory marker, and insulin resistance and type 2 diabetes risk--lipoprotein insulin resistance index and diabetes risk index (all PCRvsAL≤0.
0009) decreased
.
4 kg; 7.
5 kg), fat mass (6.
1 kg; 5.
3 kg), and fat-free body mass (2.
20 kg; 2.
17 kg), but cardiovascular disease risk markers, lipoprotein B, and inflammatory The marker GlycA, as well as insulin resistance and type 2 diabetes risk, the lipoprotein insulin resistance index and diabetes risk index (all PCRvsAL ≤ 0.
0009) decreased
.
Not only were there decreases in able body weight (8.
Further analysis revealed that the improvements in insulin resistance and diabetes risk stemmed from CR-induced changes in lipoproteins, specifically a reduction in triglyceride-rich lipoprotein particles and low-density lipoprotein particles in favor of larger high-density lipoprotein particles ( more efficient cholesterol transporter), and a reduction in branched-chain amino acids (BCAAs) (all PCRvsAL ≤ 0.
004)
.
These CR responses were more pronounced in overweight participants than normal weight participants, and more pronounced in men than women
The improvement in insulin resistance and diabetes risk stems from CR-induced changes in lipoproteins, specifically a reduction in triglyceride-rich lipoprotein particles and low-density lipoprotein particles, and a shift towards larger high-density lipoprotein particles (the more potent cholesterol transport vehicles), and a reduction in branched-chain amino acids (BCAAs) (all PCRvsAL≤0.
In conclusion, 12-month calorie reduction in normal to slightly overweight adults with no apparent risk factors or disease improved newly identified risk of atherosclerotic cardiovascular disease, insulin resistance, and type 2 diabetes marker
references:
Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.
Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.
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