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With the improvement of living standards, people pay more and more attention to the balance of nutritional status
.
Studies have shown that up to 52% of people are taking various nutritional supplements
Up to 52% are taking various nutritional supplements
screening
Participants were randomly assigned (1:1) to receive either a 60,000 IU vitamin D3 oral gel capsule or a placebo once a month for 5 years
.
The primary endpoint was to assess all-cause mortality in all randomly assigned participants
Blood vessel
Between February 14, 2014, and June 17, 2015, 21,315 participants were randomly assigned, including 10,662 to the vitamin D group and 10,653 to the placebo group
.
Among 4441 blood samples collected from randomly sampled participants (N = 3943) during follow-up, the mean serum 25-hydroxy-vitamin D concentration was 77 in the placebo group and 115 nmol/L in the vitamin D group
After 5 years of intervention (median follow-up 5.
7 years [IQR 5.
4-6.
7]), 1100 deaths were recorded (placebo 538 [5.
1%]; vitamin D 562 [5.
3%])
.
Overall, vitamin D3 had no effect on all-cause mortality (HR=1.
Overall, vitamin D3 had no effect on all-cause mortality (HR=1.
Changes in mortality with vitamin D versus controls during follow-up
The odds for each protocol analysis was OR = 1.
18 (95% CI 1.
00-1.
40; p = 0.
06)
.
In an exploratory analysis that excluded the first two years of follow-up, those randomly assigned to receive vitamin D had an even higher risk of cancer death than those in the placebo group (HR 1.
In an exploratory analysis that excluded the first two years of follow-up, those randomly assigned to receive vitamin D had an even higher risk of cancer death than those in the placebo group (HR 1.
In conclusion, monthly administration of vitamin D3 to unscreened older adults did not reduce all-cause mortality
references:
The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality.
The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality.
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