Lancet Sub-Journal: Attention, pregnant mothers-not only will depression after delivery, but also increase the incidence of other mental disorders!

For many years, the controversy over the status of postpartum mental disorders has hindered research, caused considerable confusion for clinicians and women, and may have negative consequences

Recently, experts from the Department of Psychological Medicine and Clinical Neuroscience of Cardiff University in the United Kingdom have speculated that genetic vulnerability is different between women with first-onset postpartum mental disorder and more generally patients with bipolar disorder .

In this case-control study on the first episode of postpartum psychosis and bipolar disorder in the UK, information on women with bipolar disorder was obtained from the bipolar disorder research network database.

2809 women were recruited from the general population through the British National Blood Service and the 1958 birth cohort (British National Child Development Research) as controls, and matched with cases based on genetic ancestry

Between September 1991 and May 2013, the researchers included 203 women with first-onset postpartum mental disorders (defined as having no history of mental illness before childbirth, and manic, mixed, or psychotic depression occurring within 6 weeks after childbirth) ( Median age at interview: 46 years old [IQR 37-55]) and 1225 women with a history of bipolar disorder (49 years old [41-58]), and 2809 control group members

Analysis of polygenic risk scores of three groups of subjects

Compared with the control group, women with first episode of postpartum psychosis increased the PRSs of bipolar disorder by 71% (RR=1.

references:

Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores.