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Over the past few decades, the life expectancy of humans worldwide has been increasing.
The period of time a person spends in a healthy state is usually called health span.
Recent studies investigating the genetic structure of the health span defined by morbidity indicate that healthy life span is a potential phenotype for studying human aging.
Serum biomarkers have always been a useful tool for predicting health risks.
A set of serum biomarkers, including blood glucose, blood lipids and inflammation markers, are routinely evaluated because they are closely related to the occurrence and development of the disease.
cholesterol
In order to explore the predictive value of common biomarkers for healthy lifespan and determine the causal mechanism of speculation, experts from the Department of Medical Epidemiology and Biostatistics of Karolinska Institute in Stockholm, Sweden carried out relevant studies, and the results were published in the latest "The Lancet " sub-issue in Ebiomedicine magazine.
Lancet
Researchers used the data of 12,098 Swedes aged 47-94 to study the serum concentrations and gene prediction levels of 10 blood glucose, lipids, inflammation, and hematological biomarkers.
Events leading to the end of healthy life and risk index of all chronic events and deaths
Events leading to the end of healthy life and risk index of all chronic events and deathsThe results showed that 7 out of 10 serum biomarkers were clearly associated with any risk of chronic disease and death.
Among them, the increase in blood glucose and HDL-C-related biomarkers showed the strongest harmful effects (HR=1.
The genetic predisposition for elevated fasting blood glucose is associated with a 5% increase in the risk of all chronic diseases, and a higher genetically determined CRP is associated with a 9% reduction in the risk of death.
The relationship between serum clinical biomarkers and health span and life span
The relationship between serum clinical biomarkers and health span and life spanIn summary, if you want to live a healthy and long life, blood sugar control is a potential intervention target to maintain a healthy lifespan.
In summary, if you want to live a healthy and long life, blood sugar control is a potential intervention target to maintain a healthy lifespan.
references:
Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data.
Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data.
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