Lancet Sub-Journal: Health during pregnancy affects the occurrence of thyroid cancer in offspring

Recently, the latest Global Cancer Burden Report 2020 was released by the International Agency for Research on Cancer (IARC), part of the World Health Organization, which provides a comprehensive analysis of the types of cancers common around the world, the types of major cancers that cause death, and future cancer trends by 2020.
, there will be 19.3 million new types of cancer and nearly 10 million deaths in 2020, according to new cancer data.
almost one in five people will develop cancer in their lifetime, and one in eight men and one in 11 women will die of cancer.
, thyroid cancer (thyroid carcinoma, TC) is the fifth most common type of cancer among women among women and the second most common cancer among women under the age of 40.
TC has a significantly higher incidence rate among women, with a ratio of 1:2-3 for men and women.
TC is visible at any age, with elevated incidence beginning in adolescence (10-14 years) and peaking in childbearing age (15-44 years).
the past few decades, the incidence of TC has increased significantly, and many studies have suggested that it may be closely related to environmental and hormonal exposure.
addition, the currently recognized risk factors for changing TC are obesity and exposure to ionizing radiation in childhood, and the earlier exposure to risk factors, the higher the incidence.
this particular age and gender pattern, allowing researchers to focus on specific hormone exposure and the critical time window for exposure.
to this end, the team, led by the National Cancer Institute, looked at the effects of pregnancy health and early-life exposure on the risk of thyroid cancer in future generations, and published the results in the latest issue of The Lancet- Diabetes and Endocrinology. In the journal Diabetes and Endocrinology.
team assessed the relationship between medding's medical history, pregnancy complications and birth characteristics and the risk of TC in offspring, based on registration data from the four Nordic countries.
patients born in Denmark in 1973-2013, Finland in 1987-2014, Norway in 1967-2015 or Sweden in 1973-2014 matched the control group by a ratio of up to 1:10, depending on the year of birth, sex, country and region of birth.
2437 TC patients were included in the study.
1967 (81.4%) were thyroid papyrotic cancer, 11.6% thyroid foam cancer and 5.7% myelin cancer.
1,880 cases (77.1%) were female and 1,384 (56.7%) were under the age of 30 at the time of diagnosis.
Compared to the control group, the following maternal factors may be associated with an increased risk of TC in offspring: 1) higher birth weight (14% increase in the risk of TC for each additional kg); Bleeding (risk increased by 28%); 5) pregnancy plus or minus or methagar (risk was 18.12 and 11.91 times respectively in the control group); 6) the mother had a history of goiter or benign tumors of the goiter (risk was 67.36 and 22.50 times higher in the control group), and the relationship between maternal history, pregnancy complications and birth characteristics and the risk of offspring TC.
study concluded that intrawomb exposure factors, especially those associated with thyroid disease during pregnancy, may have a long-term effect on the risk of TC in future generations.
, the study provides an important sentence for the relationship between intrauterine exposure and increased risk of thyroid development in future generations.
we need more research to further explore the relationship between the two.
: Kitahara CM, Sletteb s Daltveit D, Ekbom A, et al. Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study. Lancet Diabetes Endocrinol. 2020 Dec 18:S2213-8587(20)30399-5. doi: 10.1016/S2213-8587 (20) 30399-5. MedSci Original Source: MedSci Original Copyright Notice: All noted on this website "Source: The text, images and audio and video materials of Metz Medicine or Source: MedSci Originals are owned by Metz Medicine and may not be reproduced by any media, website or individual without authorization, and shall be reproduced with the words "Source: Mets Medicine".
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