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In low- and middle-income countries, the incidence and mortality of cervical cancer are high.
Quadrivalent HPV vaccine can be effectivePrevention prevention prevention of cervical high-grade intraepithelial lesions.
Immunization with HPV vaccine can prevent HPV infection, genital warts, and high-grade cervical intraepithelial lesions.
However, most cervical high-risk HPV infections are short-lived, and only a small percentage develop into cervical cancer.
Family clustering studies and heritability estimates indicate that there is a significant genetic component.
The results revealed three genes and two major behavioral risk factors related to the increased risk of cervical cancer.
The researchers used data from the UK Biobank to conduct a GWAS population study in a cohort of unrelated European individuals.
A total of 4769 CIN3 and invasive cervical cancer case samples and 145,545 control samples were included in GWAS.
These include PAX8 (rs10175462), CLPTM1L (rs27069), HLA-DQA1 (rs9272050), MICA (rs6938453), HLA-DQB1 (rs55986091) and HLA-B (rs9266183).
Subsequently, an independent Finnish dataset of 1648 cases of invasive cervical cancer was verified and found that PAX8, CLPTM1L and HLA-DQA1 mutations were associated with an increased risk of cervical cancer.
PAX8, CLPTM1L and HLA-DQA1 mutations are associated with an increased risk of cervical cancer.
Smoking can increase the risk of cervical cancer by 146% (OR=2.
For this reason, the results of this study provide new evidence for the genetic susceptibility of cervical cancer, especially PAX8, CLPTM1L and HLA genes, suggesting the effects of apoptosis and interruption of immune function pathways on the occurrence and development of the disease.
In particular, PAX8, CLPTM1L and HLA genes suggest the effects of apoptosis and interruption of immune function pathways on the occurrence and development of diseases.
The study revealed three genes and two major behavioral risk factors related to the increased risk of cervical cancer, providing evidence for future personalized screening and treatment of cervical cancer .
references:
Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.
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