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Lancet Sub-Journal: Routine use of levothyroxine does not improve live birth rates in euthyroid TPO-Ab-positive women with recurrent miscarriage

 Last Update: 2022-04-17
 Source: Internet
 Author: User

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Thyroid peroxidase antibody (TPO-Ab)-positive women have a higher risk of recurrent miscarriage than the general population
.

It is not known whether levothyroxine therapy improves pregnancy outcomes in women who are TPO-Ab positive and have a history of recurrent miscarriage

The purpose of this study (T4LIFE) was to determine whether levothyroxine increases live birth rates in TPO-Ab-positive women with a history of recurrent miscarriage and euthyroidism
.

This is an international, double-blind, placebo-controlled Phase 3 trial recruiting TPO-Ab-positive women aged 18-42, with ≥2 miscarriages, with normal thyroid stimulating hormone (TSH) levels, and excluded Antiphospholipid syndrome, other autoimmune diseases, thyroid disease patients
.

Patients were randomized 1:1 into two groups to receive oral levothyroxine (0.

Live birth rates in both groups

Between January 1, 2013, and September 19, 2019, a total of 187 women were recruited: 94 (50%) were assigned to levothyroxine and 93 (50%) were assigned to placebo
.

47 (50%) and 45 (48%) women in the levothyroxine and placebo groups, respectively, delivered their newborns successfully (hazard ratio 1.

187 Forty-seven (50%) and 45 (48%) women in the levothyroxine and placebo groups, respectively , delivered their newborns successfully (hazard ratio 1.

Levothyroxine did not increase the live birth rate compared with placebo in TPO-Ab-positive euthyroid women with a history of recurrent miscarriage Live birth rates in euthyroid women with a history of recurrent miscarriage TPO-Ab positive euthyroid women with a history of recurrent miscarriage

Original source:

Myrthe M van Dijk, et al.

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