Lanzhou Veterinary Institute reveals the fatal structural weakness of O virus itself

A few days ago, the host antiviral infection and immunobiology innovation team of the Lanzhou Veterinary Institute has made new progress in the study of the foot-and-mouth disease virus (FMDV) antigen structure, using bovine broad-spectrum neutralizing antibodies to reveal new cross-protective antigen sites on the surface of the O-type FMDV capsid Structural information, reported a virus neutralization mechanism of a bovine-derived neutralizing antibody that rapidly splits the virus, which provides strong support for the future research of FMD broad-spectrum vaccines

This study used 13 broad-spectrum neutralizing antibodies of bovine origin to analyze the structure of two cross-protective antigen sites on the surface of the O-type foot-and-mouth disease virus capsid, one located in the VP2 protein, and the other located in the VP3 protein, containing different conformational epitopes.

This research was completed by the State Key Laboratory of Pathogenic Biology of Livestock Diseases and the National Foot-and-Mouth Disease Reference Laboratory, and was funded by the National Natural Science Foundation of China (no.

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