Latest release! Data sharing and analysis system of global coronavirology

Coronavirus is a large class of virus, which is known to cause diseases Patients show different clinical symptoms from common cold to severe pulmonary infection, such as Middle East respiratory syndrome (mers) and severe acute respiratory syndrome (SARS) The novel coronavirus novel coronavirus novel coronavirus 2019-nCov discovered in Wuhan is a new coronavirus that has not been found in humans It belongs to the coronavirus beta WHO has officially named the pneumonia caused by the new coronavirus infection COVID-19 To support China's novel coronavirus infection prevention and control and scientific research, the national Microbial Science Data Center, sponsored by the Institute of Microbiology, Chinese Academy of Sciences, released the global http://nmdc.cn/#/ coronavirus data sharing and analysis system in February 18, 2020 The system integrates coronavirus gene and whole genome data, and integrates similarity comparison, system evolution analysis and other tools to realize global virology data integration and process analysis and mining, to help the research of virus variation, traceability, evolution, etc., and to promote the collection, comprehensive analysis and sharing of coronavirus data at home and abroad At present, the database integrates 3135 global coronavirus genomes including the new coronavirus genome data, 32865 nucleic acid sequences, from 20241 strains, 496 different host types and 568 collection sites Figure: the global coronavirus genomic data sharing and analysis system provides users with similarity query analysis and phylogenetic analysis based on uploaded genome sequences, amplified partial sequences or translated protein sequences and data in the database The function of similarity query and analysis module can provide users with sequence alignment analysis of functional genes and genome sequences at the level of nucleic acid and protein Phylogenetic analysis module can provide users with the evolution analysis of key coronavirus proteins, including spike protein, capsid protein, membrane protein and other proteins closely related to identification, transmission, infection and reproduction of coronavirus, so as to speculate the evolution relationship and direction Figure: similar sequence query result figure: after the start of S-protein phylogenetic tree example service system, the data platform of coronavirus group will be further improved and integrated, and the genotype and phenotype information of pathogen will be integrated, so as to realize early warning and prevention of infectious diseases and provide data guarantee for national biosafety The system is supported by national science and technology resource sharing service platform, capacity building of Microbial Science Data Center of Chinese Academy of Sciences (0203), earth big data pilot class a project of Chinese Academy of Sciences (xda19050301), strategic biological resource plan of Chinese Academy of Sciences (kfj-brp) and other projects Jeni turtle