Latest study: Inhibition of kinase GCN2 improves liver lipid deposition in obese mice

With the rapid changes in life>29% .
Nearly one-third of Chinese people suffer from non-alcoholic fatty liver
.

It is estimated that by 2030 , there will be as many as 300 million fatty liver patients in China , which will become the biggest burden in the prevention and control of chronic diseases .
The further development of fatty liver can cause steatohepatitis, liver fibrosis, liver cirrhosis and liver cancer .
Compared with the attention to diabetes and high blood pressure, non-alcoholic fatty liver is a major health threat that is seriously underestimated .
2021 Nian 12 Yue 23 days, College of Life magazine Lu Zhongbing research group in the field of oxidative stress and free radicals authority Redox Biology Online published an article Title ldquo &; Inhibition of hepatic steatosis and GCN2 alleviates oxidative Stress in the MICE Obese: Involvement of NRF2 The research paper of regulation ” reveals the molecular mechanism of inhibiting the kinase GCN2 to improve liver lipid deposition and oxidative stress in obese mice

This study first confirmed in cells and animal models that GCN2 can regulate NRF2, a key transcription factor against oxidative stress, in an expression- and activity-dependent manner
.

Co-immunoprecipitation and truncation experiments confirmed that GCN2 interacts with the Neh2 domain of NRF2 through its C- terminus to mediate the degradation of NRF2 in a KEAP1- dependent manner .

Dr.

Juntao Yuan, a postdoctoral fellow from the School of Life Sciences, is the first author of this paper, and students such as Yu Zhuoran and Gao Junling also made certain contributions

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