-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
A sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for a novel peroxisome proliferator-activatedreceptor γ (PPARγ) agonist, KR-62980, in rat plasma. It involves liquid–liquid extraction (LLE) followed by HPLC separationand electrospray ionization tandem mass spectrometry. The linear ranges of the assay were 0.01–10 μg/mL with a correlationcoefficient (
R2
) greater than 0.99 and the lower limit of quantification was 0.01 μg/mL. The average recovery was 90.1 and 98.4% from ratplasma for KR-62980 and imipramine, respectively. The coefficients of variation of intra- and inter-assay were 1.2–10.6% andthe relative error was 0.8–13.2%. The method was validated and successfully applied to the pharmacokinetic study of KR-62980in rat.