LCAH: Physical and mental health of UK adolescents 3 months after SARS-CoV-2 infection (CLOCK)

Background: We describe the post-COVID symptomatology of a cohort of 11-17-year-old adolescents with PCR-confirmed SARS-CoV-2 infection and PCR-negative matched adolescents
.

We describe the post-COVID symptomatology of a cohort of 11-17-year-old adolescents with PCR-confirmed SARS-CoV-2 infection and PCR-negative matched adolescents
.

Methods: In this national cohort study, adolescents aged 11-17 who tested positive for SARS-CoV-2 in the Public Health England database from January to March 2021 were compared by month of testing, age, gender and geographic region with negative testing teens are matched
.

Three months after the end of the test, a detailed questionnaire was administered to a group of adolescents to collect demographic and physical and mental health data at the time of PCR testing (retrospective) and at the time of questionnaire completion (prospective)

Results: Between January 1, 2021 and March 31, 2021, a survey of 23,048 adolescents who tested positive and 27,798 who tested negative, 6,804 adolescents (3,065 positive and 3,739 negative) completed Questionnaire survey, the response rate was 13.
4%
.

PCR test was positive in 1084 cases (35.

Table 1: Baseline characteristics of all study participants who completed the 3-month questionnaire

Table 1: Baseline characteristics of all study participants who completed the 3-month questionnaire

Table 2: Symptoms reported at the time of testing and pre-test physical and mental health by SARS-CoV-2 status, overall, and age group

Table 2: Symptoms reported at the time of testing and pre-test physical and mental health by SARS-CoV-2 status, overall, and age group

Table 3: Symptoms reported by SARS-CoV-2 status at 3 months, overall and stratified by age group

Table 3: Symptoms reported by SARS-CoV-2 status at 3 months, overall and stratified by age group

CONCLUSIONS: Adolescents who tested positive for SARS-CoV-2 had similar symptoms to those who tested negative, but had a higher prevalence of single symptoms, especially multiple symptoms, at the time of PCR testing and 3 months later
.

Clinicians should consider multiple symptoms affecting function and identify distinct symptom clusters

Adolescents who tested positive for SARS-CoV-2 had similar symptoms to those who tested negative, but the prevalence of single symptoms, and especially multiple symptoms, was higher at the time of PCR testing and 3 months later

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.
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