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LDE: In the DAPA-CKD trial, proteinuria and eGFR slope are used to predict treatment response

 Last Update: 2021-11-12
 Source: Internet
 Author: User

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Dapagliflozin and the Prevention of Adverse Outcome of Chronic Kidney Disease (DAPA-CKD) trial is a landmark study.

Established SGLT2 inhibitors as a new standard for the treatment of patients with type 2 diabetes and chronic kidney disease

The main result of dapagliflozin (estimated glomerular filtration rate [eGFR] decreased by 50%, renal failure, or death from kidney disease or cardiovascular disease) was positive (hazard ratio 0.

In the journal "The Lancet Diabetes and Endocrinology", two articles conducted a preliminary analysis of proteinuria and eGFR over time

Dapagliflozin reduced the proteinuria of participants with chronic kidney disease, and the reduction was greater in patients with type 2 diabetes, high HbA1c or diabetic nephropathy.

Intensive treatment

Original source:

Tuttle KR, Forecasting therapeutic responses by albuminuria and eGFR slope during the DAPA-CKD tria l.

Forecasting therapeutic responses by albuminuria and eGFR slope during the DAPA-CKD tria

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