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    Home > Active Ingredient News > Study of Nervous System > Learning ability is not comparable to that of elementary school students? Yes, because of this chemical in the brain!

    Learning ability is not comparable to that of elementary school students? Yes, because of this chemical in the brain!

    • Last Update: 2023-02-01
    • Source: Internet
    • Author: User
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    Although you live to learn, when you grow up, your ability to learn new knowledge seems to be far less than that of adolescence, and even if you do, you will forget it in a few days - this is not an illusion, a study published in Current Biology shows that children do learn more efficiently than adults, and the key to this is a chemical
    called GABA in the brain.

    GABA is an amino acid that is ubiquitous in
    vertebrates, plants, and microorganisms.
    In the central nervous system, GABA belongs to inhibitory neurotransmitters, that is, it is equivalent to a "calming and sedative" signal, which can reduce the excitability of neurons and even the entire nervous system, and has a certain anti-anxiety and sleep improvement effect
    .
    Recently, a study published in Current Biology, "
    Efficient learning in children with rapid GABA.
    " boosting during and after training
    " shows that GABA can help children absorb and consolidate new knowledge
    more quickly.


    Figure 1 Research results (Source: [1])


    Effective learning means being able to learn more content in a given amount of time, which requires learners to quickly consolidate the learning content after training, that is, stabilize the fragile and malleable learning state after training into a solid memory
    that is not disturbed by new learning content.
    Past studies in adults have shown that GABA plays an important role in stabilizing learning status, while in children, the GABA-dependent system is not fully mature, and GABA levels are low, so it is concluded
    that children are not as efficient as adults.


    However, previous studies have not combined the measurement of GABA with specific stages of learning (i.
    e.
    , before, during, and after learning), so it is difficult to reveal the mechanism
    behind GABA's impact on learning efficiency.
    To this end, a neuroscience research team from Brown University in the United States and the University of Regensburg in Germany compared the changes in GABA concentrations in the visual cortex before, during and after the start of visual learning tasks in children (8 to 11 years old) and adults (18 to 35 years old), hoping to find answers
    .


    The results showed that children did have less total GABA in their bodies than adults before learning began, however during learning, children showed a rapid increase in GABA concentration, and this increase persisted even for some time after the training ended
    .
    The GABA level of adults did not fluctuate
    throughout the experiment.
    This suggests that GABA concentrations in children rapidly increase as new learning programs unfold, quickly stabilizing
    their fragile and malleable learning state.


    Fig.
    2 Changes of GABA concentration before, during and after training (Source: [1])


    Subsequent behavioral experiments confirmed this
    .
    The researchers had children and adults train in two similar programs on the first day, 10 minutes apart, and evaluate the effects of both programs on the second day
    .
    The results of the evaluation showed that children "learned" in both trainings, while adults only reflected the results of
    the training in the second training.

    Figure 3 Design and results of behavioral experiments (Source: [1])


    Sebastian M.
    Frank, lead author of the study and now at the University of Regensburg in Germany, said: "This shows that children do stabilize new learning faster than adults, which is consistent with
    the general view that children's learning ability is better than that of adults.
    " Children are able to stabilize within minutes of the end of the course, while adults remain in a "fragile and malleable" state for at least an hour after the course ends, and are therefore more susceptible to retrograde interference, where later learning affects the consolidation
    of prior knowledge.


    Figure 4 Conceptual diagram of GABA level change to support children's efficient learning (Source: [1])


    The researchers also found that continuous learning appeared to further increase GABA concentrations in children, allowing for faster stabilization of previous learning
    .
    This will further encourage teachers and parents to provide more opportunities for children to learn new skills and potentially change neuroscientists' perception of
    children's brain maturity.


    Frank said: "Although children have poor inhibitory performance in areas such as cognitive control or attention, children have shown efficient GABA inhibition mechanisms and are better capable than adults
    ," Frank said.
    "This means that GABA inhibitory mechanisms may mature at different rates when it comes to cognitive different functions
    .
    "


    Takeo Watanabe, a cognitive psychologist at Brown University and senior author of the study, believes that although the study revolves around visual learning, the findings can be generalized to other types of learning
    .
    The results will also help adults learn more efficiently," for example, by developing new therapies
    that increase the amount of GABA in the adult brain.


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    Resources:

    [1] Frank SM, Becker M, Qi A, et al.
    Efficient learning in children with rapid GABA boosting during and after training.
    Curr Biol.
    2022 Dec 5; 32(23):5022-5030.
    e7.
    doi: 10.
    1016/j.
    cub.
    2022.
    10.
    021.

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