Summary of experience in NBS bromination reaction
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Last Update: 2020-10-26
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Source: Internet
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Author: User
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related topics . NBS bromination
reagents
and brominated reaction
this afternoon steamed NBS brominated products, the results of the afternoon are tears and snot flow together, finally confirmed that: the resulting product is not bromine 2-ph-toluene, but a very strange eye and nose with strong irritation of red-brown liquid, very failed! I'm in a bad mood this afternoon. At first it was thought to be ether or CCl4, but then it was unlikely that the smell of a ether or carbon tetrachloride would be completely different. Finally accepted the fact that the bottle I added last week suspected that either CCl4 liquid might be CCl4!to do bromine reaction, these times have failed, sum up the experience and lessons: 1, solvent must be a lot, its own CCl4 to NBS solubility is not good, plus less is the opposite should be;2, stirring must be good,
large
and large mixer;3, NBS and AIBN to join in batches, do not worry, the speed is not up to, this sentence is used in the experiment is too right;3, reaction time can be a little longer, 5h or more can be.
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