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Leukemia: Comprehensive clinical evaluation of Guadecitabine (SGI-110) in peripheral T-cell lymphoma

 Last Update: 2022-05-26
 Source: Internet
 Author: User

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Peripheral T-cell lymphoma (PTCL) is a rare, heterogeneous malignancy that relapses with poor patient outcomes

Hypomethylating agents (HMAs) are a class of epigenetic antineoplastic drugs that have been previously shown to have a role in PTCL, along with genetic mutations shared with myelodysplastic syndromes (MDS)

In this phase II, single-arm trial, patients with PTCL received guadecitabine on days 1-5 of a 28-day treatment cycle

Wong, J.

https://doi.
org/10.
1038/s41375-022-01571-8

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