Li Yongbo: Infant milk protein allergy? Scientific feeding is key!

In recent years, the incidence of allergic diseases has increased dramatically globally, and in order to raise awareness of allergies, the
World Allergy Organization (WAO) defines July 8 as World Allergy Day, and on the occasion of World Allergy Day this year, Professor Li Yongbai, Chief Physician of Shenzhen Children's Hospital, has issued an academic opinion on "Infant Allergy Prevention", emphasizing that infant milk protein allergy needs urgent attention and that clinically proven moderate hydrolyceric protein formulations can help reduce allergy risk in infants and young children.is the best nutritional strategy for infant and young child allergy preventionWith the increasing incidence of allergic diseases in children in recent years, more and more attention has been paid to the promotion and popularization of allergic diseases in children.the results of the China Urban Allergy Disease Epidemiology Survey showed that the total prevalence of allergic diseases in infants and young children between the age of
0-24 months was 12.3%, and 40.9% of parents of infants and young children between 0 and 24 months of age reported that their children had or were having symptoms of allergic diseases.there is no cure for allergic diseases, which places a greater burden on the families and society of the affected children. Therefore, the early prevention of allergic diseases in infants and young children is of great significance. Breastfeeding helps to avoid the intake of allogeneic proteins, thereby reducing the number of allergens, reduce the risk of allergic diseases, is the best nutritional strategy for infant allergy prevention.More thanclinical studies have confirmed that breastfeeding reduces the risk of food allergies, eczema, and wheezing in infants before the age of
2, and authorities such as the American Academy of Pediatrics and the Chinese Academy of Medicine recommend exclusive breastfeeding for the first 4 to 6 months of life.When breast milk is insufficient, scientific feeding can help reduce the risk of milk protein allergy milk protein is a more common allergen in early life in infants and young children, and milk protein allergy
(Cow's Milk Protein Allergy, CMPA) typically occurs within 1 year of age in children, a period when the neonatal intestinal barrier function is still quite immature. Studies in some cities in China show that the prevalence of CMPA in infants and young children aged 0 to 3 is about 0.83% to 3.5%. Studies have shown that breastfeeding for at least 4 months can prevent or alleviate a child's milk allergy.For children at high risk of not being exclusively breastfed or breastfed, clinically proven moderate hydrolyzed protein formulations prevent the occurrence of early-stage endexual dermatitis and
CMPA in infants and young children compared to common milk protein formulations.Moderate hydrolyzed protein refers to the hydrolyzing of highly allergenic common milk protein into a low-allergenic small molecule protein through a specific high temperature and enzyme hydrolyzing process, which helps to reduce the risk of allergy in infants and young children
However, not all moderate hydrolysed protein formulations have the effect of reducing the risk of allergies. Among them, the allergy prevention effect of moderate hydrolytic 100% whey formula (Partial Hydrolysed Formula, pHF) has been tested in many studies.A meta-analysis of 15 randomized controlled clinical studies included in
confirmed that pHF reduced the risk of a variety of allergic diseases at different points in the growth and development of children, especially endexual dermatitis/eczema, compared to regular formula.Hania meta-analysis: Moderate hydrolyzing 100% whey formula reduces the risk of children's endexual dermatitisIt is worth noting that the effects of hydrolyzed protein formulations in preventing allergic diseases need to be confirmed by clinical studies and are independent of both protein source and hydrolytic level
Moderate hydrolytic formula is sufficiently nutritious and safe to feed for long periods of time based on protein processing technology, moderate hydrolytic
100% whey formulation contains essential amino acids and branched chain amino acids close to breast milk, can provide long-term nutrition, support the healthy growth of infants.German Infant Nutrition Intervention
GINI study's six-year follow-up results confirmed that infants fed a moderate hydrolytic 100% whey protein formula had a growth curve similar to that of breastfed infants at 6 months of life and at all points in time between the age of follow-up and the age of 6. The study confirmed that the moderate hydrolysed formula is adequately nutritious and safe for long-term feeding.GINI study 6 years results: 100% moderate hydrolysed whey formula group vs breastfed group infant growth and development curveBreastfeeding is the best nutritional strategy for infant allergy prevention, when breast milk is insufficient or not breastfed, for infants at high risk of allergies or parents with a sense of allergy prevention, moderate hydrolytic formula can help reduce allergy risk, while meeting the nutritional needs of infants and young children. : 1
, etc.  China Journal of Child Health. 2016, 24(2):119-122. .
. Chen Jihong, etc. China Maternal and Child Health. 2008; 23(12): 1660-1661. 【
3】Dogaru CM, et al. Am J Epidemiol 2014; 179: 1153–1167. 【
4】Greer FR, Sicherer SH, Burks AW. Pediatrics. 2008; 121(1):183-91. 5
Children's Health Unit of the Paediatric Branch of the Chinese Medical Association, etc. . . Chinese Journal of Pediatrics. 2011; 49(5): 344-48. 6
Department of Immunology, Chinese Academy of Pediatrics, 2013, 51 (3): 183-186. .
. Steven, Sherf. American Academy of Pediatrics Parenting Encyclopeology , Beijing Science and Technology Press, 2016. 【
8】Szajewska et al, Current Medical Research and opinion 2010; 26: 423-37. 【
9】von Berg, et al. J Allergy Clin Immunol 2003; 111:533–540. 【
10】Rzehak P. et al. Am J Clin Nutr 2009; 89:1–11.