Liang Changhao, research group of Institute of solid state, Chinese Academy of Sciences and his collaborators prepared nano copper sulfide materials for tumor cell imaging and thermochemotherapy

Recently, the research group of Liang Changhao, researcher of Institute of solid physics, Chinese Academy of Sciences, and Professor Yang Xiuhua, Affiliated First Hospital of Harbin Medical University, have made progress in the preparation of multifunctional nano copper sulfide (CUS) and its anti-tumor performance research The relevant research results are published in the International Journal Biological Science (DOI: 10.1039 / c8bm01412d) As an auxiliary means of precision medicine, visualization therapy has been widely concerned in recent years The common research idea is to synthesize nano materials with imaging or therapeutic functions respectively to form composite system, but the preparation process of these strategies is relatively complex, which is not conducive to widespread promotion In recent years, multi-functional single nano materials integrated with image and treatment have good application prospects in the field of biomedicine because of their advantages such as simple preparation process and small potential side effects Among them, chalcogenides of copper are typical photothermal agents because of their high efficiency of photothermal conversion In addition, similar to GD 3 + and Fe 2 + based nanomaterials, Cu 2 + has unpaired 3D orbital electrons Therefore, there is residual magnetic moment in cus nanomaterials, which has the potential to become a magnetic resonance imaging (MRI) contrast agent Based on this, Liang Changhao's research group and Professor Yang Xiuhua, the First Affiliated Hospital of Harbin Medical University, used liquid-phase laser irradiation technology and ion replacement method to obtain single component copper sulfide flower like hollow nanospheres (CUS HNS), and put forward the application of CuS HNS in MRI guided thermochemotherapy strategy for the first time As a traditional photothermal conversion material, the synthesized cus HNS exhibits high photothermal conversion efficiency The results of in vitro MRI showed that the imaging brightness of cushns increased significantly with the increase of sample concentration on the most commonly used T1 wi and T2 FLAIR imaging sequences in clinical brain examination Six hours after the injection of CuS HNS into the tumor, the brightness of MRI in the tumor tissue increased, which further confirmed that cus HNS has a good application prospect as T1 MRI positive contrast agent In addition, the three-dimensional hollow flower structure of copper sulfide has a large number of voids and a large specific surface area, which can realize the loading of DOX, which can reach 2.69% In vivo and in vivo studies have shown that the cus nano reagent loaded with DOX can not only achieve the functions of photothermal therapy and drug chemotherapy, but also play a synergistic role in the treatment of tumor tissue by combining the two functions It is a potential MRI guided thermochemotherapy diagnostic and therapeutic reagent This work was supported by the national key basic research and development plan of the Ministry of science and Technology (973 project), the equipment development project of the Chinese Academy of Sciences and the National Natural Science Foundation of China.