"Lianhua Qingwen Can Suppress Viruses" Hot Search Experts: No clinically proven effective

Recently, as the domestic epidemic rebounded due to the Delta mutant strain, Professor Yang Zifeng, a researcher at the Guangzhou Institute of Respiratory Health, announced to the media that “Lotus blast has an inhibitory effect on the Delta mutant strain.
” Chinese medicine once again Hot search
.

Screenshot of Xiaoxiang Morning Post Weibo

Professor Yang Zifeng mentioned that in the face of mutant strains, on the basis of previous anti-epidemic research, continue to conduct research in three aspects: diagnosis, treatment, and prevention: diagnosis is rapid screening of mutant strains, treatment is drug research, and prevention is vaccine development
.

Professor Yang Zifeng pointed out that in terms of basic research, various research institutions at home and abroad have been carrying out drug research and development
.

"Our team has also carried out drug research work on mutant strains.

Professor Yang Zifeng believes that under the new situation that variant strains are impacting our country, it is of great practical significance to make good use of proprietary Chinese medicines that have the characteristics of traditional Chinese medicine and pharmacological basis to carry out group prevention and treatment
.

Lianhua Qingwen Recipe contains Yinqiao powder and Maxing Shigan Tang, forsythia, mint, ephedra, waishuweibiao, Zuoguanzhong, Radix Isatidis to help Yinhua, forsythia clearing away heat and detoxification, and gypsum is a heavy agent for clearing air and removing heat.

In the past, it was mainly used for anti-respiratory virus therapy
.

Because of its exact clinical efficacy, it has been widely used in respiratory diseases caused by a variety of influenza virus infections, including influenza A virus infection

Runfeng, Li et al.
“Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).
” Pharmacological researchvol.
156 (2020): 104761.
doi:10.
1016/j.
phrs.
2020.
104761

The study used Remdesivir as a positive control to study the inhibitory effect of Lianhua Qingwen on the new coronavirus in an in vitro test
.

Similar to Remdesivir, Lianhua Qingwen also inhibits the replication of the new coronavirus in vitro

Effect of Lianhua Qingwen (LH) treatment on the mRNA expression of inflammatory mediators in Huh-7 cells infected with SARS-CoV-2

After Lianhua Qingwen treatment, the expression of viral particles in the cells was significantly reduced, and it can inhibit the inflammatory factors produced by virus-infected cells.
The gene expression of TNF-a, IL-6, MCP-1 and IP-10 was inhibited by Lianhua Qingwen , And have a dose-dependent relationship
.

Judging from in vitro studies, Lianhua Qingwen can indeed inhibit the new coronavirus.

Hu K, Guan WJ, Bi Y, et al.
Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial.
Phytomedicine.
2021;85:153242.
doi: 10.
1016/j.
phymed.
2020.
153242

The study included a total of 284 patients, divided into Lianhua Qingwen group and conventional treatment group, with 142 cases in each group.
The main evaluation indicators were the disappearance rate of clinical symptoms such as fever, fatigue, and cough after 14 days of treatment
.

The research and test data were analyzed by a professional third-party statistical analysis.

Regarding the nucleic acid negative rate and time of new coronary pneumonia, the nucleic acid negative rate of the treatment group after 14 days of treatment with Lianhua Qingwen Capsule was 76.
8%, and the negative time was 11 days, showing a certain trend compared with the control group
.

Compared with the conventional treatment group, the reduction in the proportion of severe transformation was reduced by 50% (2.

Zhu Conglei,Hu Fangying.
Literature analysis of Lianhua Qingwen for viral infectious diseases[J].
Journal of Yichun University,2020,12:31-36+82.

In December last year, Zhu Conglei of the Seventh People’s Hospital of Yichun City also conducted a literature analysis of 42 Lianhua Qingwen for viral infectious diseases and found that it was used for influenza, COVID-19, herpes zoster, hand, foot and mouth disease, and herpes.
The clinical effects of angina, respiratory syncytial virus infection, herpes stomatitis, and herpes simplex keratitis are good, and the effective rate of COVID-19 to relieve fever is 95.
77%
.

It is concluded that Lianhua Qingwen has a good clinical effect on viral infectious diseases, and it has been proven to inhibit the activity of the new coronavirus in vitro

In summary, at present, only a small amount of in vitro test data confirms the inhibition of the activity of the new coronavirus in vitro and the remission of a small number of ordinary new coronavirus patients.
It has not been widely clinically proven to be effective, and there are few safety studies.
In the future, more prospective and Randomized controlled clinical studies to further evaluate the safety and effectiveness of the improved medication regimen
.
Therefore, I would like to remind everyone once again that we should take a rational view of the effectiveness of Lianhua Qingwen
.

Reference materials:

1.
Wang Xingong, Cui Xuejun, Liu Xinsheng.
Observation on the clinical efficacy of Lianhua Qingwen Capsule in the treatment of influenza [J].
China Pharmacy, 2008, 19(27): 2146.
2148

2.
Runfeng, Li et al.
"Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).
" Pharmacological researchvol.
156 (2020): 104761.
doi:10.
1016/j.
phrs.
2020.
104761

3.
Hu K, Guan WJ, Bi Y, et al.
Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial.
Phytomedicine.
2021;85:153242.
doi:10.
1016/j.
phymed.
2020.
153242

4.
Zhu Conglei, Hu Fangying.
Literature analysis of Lianhua Qingwen for viral infectious diseases[J].
Journal of Yichun University, 2020,12:31-36+82.