Lilly's RET inhibitor shows long-term efficacy in the precise treatment of non-small cell lung cancer

▎WuXi AppTec Content Team Editor A few days ago, Eli Lilly and Company today announced updated data from a Phase 1/2 clinical trial of the RET inhibitor Retevmo (selpercatinib) in patients with RET fusion-positive non-small cell lung cancer (NSCLC)
.

Trial results showed that Retevmo brought sustained remission to patients at a median follow-up of about two years
.

Retevmo, a potent RET kinase inhibitor, received its first accelerated approval from the U.
S.
FDA in 2020 for the treatment of three cancers, non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC) and thyroid cancer
.

These patients' tumors had fusions or mutations in the RET gene
.

The newly published clinical trial data included 355 patients eligible for efficacy analysis, 247 of whom had previously received at least first-line platinum-containing chemotherapy and 69 treatment-naïve patients
.

58% of patients received anti-PD-1 or anti-PD-L1 antibody therapy
.

The confirmed objective response rate (ORR) was 61.
1% (95% CI: 54.
7-67.
2%) in patients who had received platinum-based chemotherapy and 84.
1% (95% CI: 54.
7-67.
2%) in 69 treatment-naïve patients : 73.
3-91.
8%)
.

Twenty-six patients had measurable central nervous system (CNS) metastases at baseline, and treatment with Retevmo resulted in a CNS ORR of 84.
6%
.

At a median follow-up of approximately 2 years in treatment-naïve and platinum-chemotherapy-experienced patients, median duration of response (DoR) was 20.
2 months and 28.
6 months, and median progression-free survival (PFS) estimates were 22.
0 and 22.
0 months, respectively.
24.
9 months
.

Among 26 patients with evaluable CNS disease, the median intracranial PFS with Retevmo was 19.
4 months
.

These median estimates are still premature
.

"These results continue to provide evidence that Retevmo is delivering meaningful clinical improvement in patients with metastatic RET fusion-positive NSCLC, including those with difficult-to-treat brain metastases
,
" said Dr.
David Hyman, chief medical officer, Lilly Oncology
.

Reference: [1] Lilly Presents Updated Data on Retevmo® (selpercatinib) in Advanced RET Fusion-Positive Non-Small-Cell Lung Cancer (NSCLC) at the 2022 European Lung Cancer Congress.
Retrieved April 1, 2022, from https:/ /investor.
lilly.
com/news-releases/news-release-details/lilly-presents-updated-data-retevmor-selpercatinib-advanced-ret.
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.

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.

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