Limited-time eating improves health without changing the body's core clock

said
to metabolic health, not just what to eat, but when to eat. Studies have shown that one effective way to lose weight and tackle obesity is to reduce the amount of time you eat through the day. Limited-time eating - also known as intermittent fasting - has also shown that health can improve even before weight loss begins.Little is known about the biological explanation of this phenomenon. As a result, scientists from the University of Copenhagen, the Australian Catholic University and the Karolinska Institute studied the body's early adaptation to limited-time eating. Their study found some key changes in muscle genetic activity and muscle fat and protein content, which could explain the positive effects of limited-time eating.

new insights into eating during short periods ofThe study is the first time scientists have studied oscillations in skeletal muscles and metabolites in the blood, as well as gene expression in skeletal muscles after limited-time eating. By focusing on the short- and early-stage effects of limited-time eating, the goal is to separate health control signals from weight loss-related signals."We observed that the rhythms of the skeletal core clock gene are not affected by time-limited eating, suggesting that any difference is driven more by diet than by inherent rhythms," said Leonida Rendell, a postdoctoral fellow at the Noor and Nord Foundation's Center for Basic Metabolism Research (CBMR) at the University of Copenhagen.
We also found that after limited-time eating, the metabolites of skeletal muscles changed from mainly lipid-based to amino acids, consistent with rhythmic changes in amino acid transport proteins, suggesting that some amino acid spectra may have been absorbed from the blood.Evelyn Parr, a researcher at the Mary McKillop Institute of Health at the Australian Catholic University, added: "Our study is an important step towards understanding how a limited-time diet can improve metabolic health, while bridging the gap between animal modelling and human intervention studies. It is important to capture these early metabolic reactions before assessing that time-limited eating patterns may change over a longer period of time.Eating behaviors did not affect the body's core clockIn the study, 11 overweight/obese men were assigned to a
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diet that either had no restrictions on eating or an eight-hour limit on eating. On the fifth day, sample every four hours throughout the day. After a 10-day break, they repeated the experiment according to another diet.After each intervention, the team studied gene expression in muscles and the distribution of metabolites (molecules formed through metabolic processes) in the blood and muscles.They found that limited-time eating altered the rhythmic concentration of metabolites in the blood and muscles. Limited-time eating also affects the rhythmic expression of genes expressed in muscles, especially those responsible for helping to transport amino acids, which are part of proteins.Crucially, the study showed that limited-time eating does not change the muscle's core clock, the beater within the cell that regulates its daily activity cycle. This suggests that changes in metabolites and gene expression rhythms caused by limited-time eating may be the cause of positive health effects.“ Our findings open up new avenues for scientists interested in understanding the causal relationship between limited-time eating and improved metabolic health. Professor Jolene Zirat, of the Karolinska Institute and CBMR at the University of Copenhagen, said: "These insights could help develop new therapies to improve the lives of obese patients." （cyy123.com）