Lipid metabolism disorders are the factors that influence the effectiveness of liver transplantation

18, reporters from Wuhan University People's Hospital was informed that the hospital Professor Li Hongliang's team found that: lipid metabolism disorders are the factors affecting the effectiveness of liver transplantation. According to the research results of the development of clinical drugs, it is expected to greatly improve the application of liver transplantation and treatment effect.
stage, the most common and effective treatment for advanced liver disease is liver removal and liver transplantation. Isoemia and perfusion damage to the liver are inevitable complications during the above-mentioned surgery. In order to find the root cause of liver isoemia refill injury, Professor Li Hongliang's team used a joint analysis of transcriptomics, proteomics and metabolomics to reveal for the first time the lipid metabolism disorder in isoemia stage, which is an important lesion in the process of liver isoemia refill injury.
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published online Li Hongliang's team in the field of liver ischemia refill injury of the latest research results. This study suggests that the root cause of liver isoemia refill damage is the reconstruction of lipid signal network in isoemia stage. The study has led international scholars to re-understand the underlying pathogenesis of the disease. (Source: Science and Technology Daily Liu Zhiwei Du Wei)