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Liposome small molecule mixed nanoparticles are used for fluorescence imaging and treatment of gliomas in vivo

 Last Update: 2022-10-03
 Source: Internet
 Author: User

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Recently, Zheng Huzhi et al.

——Excerpt from the article chapter

【Ref: Tang M, et al.

Research background

Liposomes are small toxicity, good biocompatibility and high degradation of materials, and their amphiphilic structure can be loaded with hydrophilic and hydrophobic drugs, which is an excellent carrier

The authors create mitochondria-targeted lipid-small molecule hybrid nanoparticles (LPHNPs)

Results of the study

The results show that: (1) The mitochondria-targeted lipid-small molecule hybrid nanoparticles constructed have higher drug loading capacity and encapsulation efficiency than traditional nanoparticles (PA@liposome), and the stability of mixed nanoparticles is higher

Conclusion of the study

In summary, the mitochondrial-targeted hybrid nanoparticles constructed in this study have the ability to target mitochondria and fluorescence imaging, which can be used for visualization of drug distribution in vivo and imaging

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