Liquid Chromatography-Mass Spectrometry of Nucleic Acids
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Last Update: 2020-12-24
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Source: Internet
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Author: User
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By virtue of its high-resolving capability, short analysis time, and advanced instrumentation high-performance liquid chromatography (HPLC) has become a versatile technique for the separation and characterization of nucleic acids. Among the various chromatographic modes, which have been summarized in several reviews (
1
–
6
), ion-pair reversed-phase HPLC (IP-RPHPLC) represents the most popular chromatographic technique applicable to the separation of single-and double-stranded
DNA
molecules.
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