Literature Discussion: Looking at the current situation of HIV drug resistance in African countries from real-world research

HIV resistance has always been an important factor affecting AIDS treatment.

In this issue, I will share with you an article published on "Open Forum Infectious Diseases" on April 22, 2022, to take us to understand the real drug resistance situation in African countries after antiretroviral therapy

Article Review

Many countries in sub-Saharan Africa started dolutegravir-based antiretroviral therapy in 2019 as the first-line treatment option for adults starting treatment, and have already switched other regimens to dolutegravir in transitional populations

By the end of March 2021, 838,000 Malawians in the national program had received a dolutegravir-based regimen; viral loads remained greater than 1000 copies/mL after 3 months of intensive adherence support in patients, according to Malawi HIV guidelines may conduct drug resistance testing

Systematic data from November 2020 to August 2021 indicated that 6462 patients with virological failure were eligible for HIV drug resistance testing

Result analysis

look back global

The report shows that the level of HIV drug resistance has risen steadily in recent years as HIV drug use continues to increase

It also pointed out that HIV drug resistance has a significant impact on AIDS deaths, new infections and treatment costs.

look at China

Source of part of the content of the literature: Youai Classroom