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The guanane-type diterpene compounds have a unique 5-6-7 tricyclic skeleton.
Such substances have a wide range of biological activities, including antiviral, anti-inflammatory, and tumor cytotoxic activities.
Among them, the most interesting is The neurotrophic effect of these substances
.
Nest diterpene found in nature only in a few large genus of fungi, including Hericium Hericium , nest genus Cyathus , meat teeth spp Sarcodon the like
The research team of Hongwei Liu from the Institute of Microbiology, Chinese Academy of Sciences has long been committed to the discovery, active mechanism, and biosynthesis of active ornithane diterpenoids.
The relevant research results have been published in Angew.
Chem.
Int.
Ed.
, J.
Biol.
Chem.
, Eur.
J .
Med.
Chem.
, J.
Antibio.
, Food Chem and other publications
.
On the basis of revealing the function of the guanane diterpene biosynthesis gene cluster and the guanane diterpene cyclase EriG, this paper realized the reconstruction of the guanane diterpene biosynthetic pathway in Saccharomyces cerevisiae, and completed 22 different structures.
At the same time, based on the heterogeneity of the substrates of glycosyltransferase EriJ, dehydrogenase EriH and FAD-dependent oxidase EriM, strains that produce new structural "non-natural" analogs were designed and constructed
.
New structural substances also exhibit neurotrophic activity on PC12 cells.
The above research results were published in Acta Pharmaceutica Sinica B, a TOP journal in Pharmacy District I in September 2021.
Ma Ke (now a postdoctoral fellow at Peking University), a doctoral student at the State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, is the first author of the paper , Researcher Liu Hongwei is the corresponding author of the paper
.
The research was supported by the National Natural Science Foundation of China and the key research and development projects of the Ministry of Science and Technology
Article information: Acta Pharmaceutica Sinica B 2021;11(9):2945e2956
Original link: https://doi.
org/10.
