Liver cancer 'behind-the-scenes pusher' found, scientists are expected to carry out a precision strike against it.

Studies have shown that about 90 percent of liver cancer patients are overactive by the Wnt signaling pathway, an important signaling system for gene regulationWhen Wnt binds to the Frizzled receptor on the surface of liver cancer cells, it initiates the Wnt signaling pathway, which transmits signals to cells, thus promoting the expression of tumor genesAs a result, liver cancer is inhibited as long as it is aimed at Wnt or Frizzled and interferes with its signal transmissionhowever, because the Wnt and Frizzled genes also play a wide role in the physiological activities of normal cells, direct attacks on them are bound to "kill a thousand enemies, self-inflicted eight hundred." The researchers then turned their attention to the GPC3 protein, the "hostage" behind them"Just as Wnt is a proliferation signal, Frizzled is a signal receiver and GPC3 is a signal enhancer unique to liver cancer cells," said Professor"GPC3 amplified the proliferation of hepatocellular carcinoma by "holding" Wnt and Frizzled, suggesting that researchers could perform precision strikes with GPC3 as a targetGorgy team analyzed the structural characteristics of GPC3, simulated the "crime process" of GPC3 holding Wnt and Frizzled, and determined the "hostage" siteAt present, the laboratory has screened a number of targeted GPC3 antibodies, including an antibody can lift GPC3 to Wnt "hostage", even if there is a large number of Wnt, liver cancer cells on the GPC3 is also "stopped" by antibodies, can no longer arbitrarily activate the Wnt signal, thereby inhibiting the proliferation of liver cancer.