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35 years old seems to be a very sensitive age label in the workplace
.
The general view is that after people reach the age of 30, various functions of the body such as metabolism begin to decline, and they eat less than before, but they grow fatter than before
.
Therefore, it gives people the feeling that "people are not as good as before when they are middle-aged"
.
This feeling may be an illusion, because a previous study published in "Science" revealed for the first time four time points in the "metabolic life stage", indicating that middle-aged weight gain is not a metabolic "pot"
.
Therefore, healthy eating and living habits can still maintain a healthy metabolic rate at the age of 35
.
However, if you're living your "peak" (too much fat and high blood sugar levels) at age 35, then you really need to be wary
.
Because, you are at great risk of developing Alzheimer's in the future
.
I believe that everyone has a good understanding of Alzheimer's disease (AD)
.
This is the most common form of dementia and there is no cure for it
.
The disease causes a rapid decline in cognitive function, along with fragmented memories, causing great distress to patients and their families
.
However, the world continues to expand the patient population at a rate of 1 new case every 3 seconds
.
It is estimated that by 2050, the number of Alzheimer's patients worldwide will increase to more than 150 million
.
Therefore, early prevention and recognition of Alzheimer's disease has become increasingly important
.
In a new study published today in Alzheimer's and Dementia: A Journal of the Alzheimer's Association, a research team led by Boston University School of Medicine (BUSM) compared people as young as 35 years old.
Cholesterol levels and blood sugar levels have been linked to future Alzheimer's risk
.
The study shows that controlling cholesterol and blood sugar levels starting at age 35 can minimize the risk of developing Alzheimer's disease in the future
.
Patients with Alzheimer's disease often exhibit features of cerebrovascular disease as well as β-amyloid (Aβ) deposition and tau hyperphosphorylation neuropathology
.
Therefore, previous studies have shown that blood cholesterol and glucose levels are associated with future risk of Alzheimer's disease
.
But this study further confirms that the effects of these risk factors come much earlier than previously thought
.
Cholesterol, as we all know, is a waxy substance in the blood
.
According to the different effects on human health, cholesterol can be divided into two types: high-density lipoprotein cholesterol (HDL-C), the so-called good cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), non-HDL -C mainly includes low-density lipoprotein cholesterol (LDL-C), the bad cholesterol
.
Extensive research has previously linked vascular and metabolic risk factors, including high levels of bad cholesterol (LDL-C) to cognitive decline and Alzheimer's risk, but good cholesterol (HDL-C) to Alzheimer's disease A link has not been established, perhaps because the baseline age of most study subjects was 55 years and older
.
In the new study, researchers looked at data from 5,124 participants aged 5 to 70 in the Framingham Heart Study
.
From 1971 to the present, these participants underwent longitudinal examinations on average every 4 years, for a total of 10
.
At each exam and at three age groups (35-50, 51-60, 61-70) in adulthood, the researchers assessed Alzheimer's disease with multiple known risk factors for cardiovascular disease and diabetes ( Includes links between good cholesterol (HDL-C), bad cholesterol (LDL-C), triglycerides, glucose, blood pressure, smoking, and body mass index)
.
They found that good cholesterol (HDL-C) levels in early (35-50 years) and mid-adulthood (51-60 years) could be a predictor of Alzheimer's disease
.
Specifically, each 15 mg/dL increase in good cholesterol (HDL-C) reduced Alzheimer's risk by 15.
4% and 17.
9% in the early and mid-adult groups, respectively
.
When adjusting for dyslipidemia treatment, the association remained significant in the mid-adulthood group.
In addition, blood glucose levels in mid-adulthood were significantly associated with Alzheimer's disease, with an effect of almost the same magnitude as good cholesterol levels, that is, for every 15 mg/dL increase , the risk of Alzheimer's increased by 14.
5%
.
(Note: normal fasting blood glucose is 70-110mg/dL) The above findings are the first to show that cardiovascular disease risk factors, including good cholesterol (HDL-C) levels, have not been considered a strong risk for Alzheimer's disease Factors, in fact, as early as age 35, these factors begin to contribute to the future development of Alzheimer's disease
.
Therefore, these factors should be carefully managed from early adulthood, with effective interventions to reduce the risk of cardiovascular disease, diabetes and Alzheimer's disease to maximize healthy living in later life, the researchers said
.
Paper link: https://doi.
org/10.
1002/alz.
12641https://science.
sciencemag.
org/content/373/6556/808
.
The general view is that after people reach the age of 30, various functions of the body such as metabolism begin to decline, and they eat less than before, but they grow fatter than before
.
Therefore, it gives people the feeling that "people are not as good as before when they are middle-aged"
.
This feeling may be an illusion, because a previous study published in "Science" revealed for the first time four time points in the "metabolic life stage", indicating that middle-aged weight gain is not a metabolic "pot"
.
Therefore, healthy eating and living habits can still maintain a healthy metabolic rate at the age of 35
.
However, if you're living your "peak" (too much fat and high blood sugar levels) at age 35, then you really need to be wary
.
Because, you are at great risk of developing Alzheimer's in the future
.
I believe that everyone has a good understanding of Alzheimer's disease (AD)
.
This is the most common form of dementia and there is no cure for it
.
The disease causes a rapid decline in cognitive function, along with fragmented memories, causing great distress to patients and their families
.
However, the world continues to expand the patient population at a rate of 1 new case every 3 seconds
.
It is estimated that by 2050, the number of Alzheimer's patients worldwide will increase to more than 150 million
.
Therefore, early prevention and recognition of Alzheimer's disease has become increasingly important
.
In a new study published today in Alzheimer's and Dementia: A Journal of the Alzheimer's Association, a research team led by Boston University School of Medicine (BUSM) compared people as young as 35 years old.
Cholesterol levels and blood sugar levels have been linked to future Alzheimer's risk
.
The study shows that controlling cholesterol and blood sugar levels starting at age 35 can minimize the risk of developing Alzheimer's disease in the future
.
Patients with Alzheimer's disease often exhibit features of cerebrovascular disease as well as β-amyloid (Aβ) deposition and tau hyperphosphorylation neuropathology
.
Therefore, previous studies have shown that blood cholesterol and glucose levels are associated with future risk of Alzheimer's disease
.
But this study further confirms that the effects of these risk factors come much earlier than previously thought
.
Cholesterol, as we all know, is a waxy substance in the blood
.
According to the different effects on human health, cholesterol can be divided into two types: high-density lipoprotein cholesterol (HDL-C), the so-called good cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), non-HDL -C mainly includes low-density lipoprotein cholesterol (LDL-C), the bad cholesterol
.
Extensive research has previously linked vascular and metabolic risk factors, including high levels of bad cholesterol (LDL-C) to cognitive decline and Alzheimer's risk, but good cholesterol (HDL-C) to Alzheimer's disease A link has not been established, perhaps because the baseline age of most study subjects was 55 years and older
.
In the new study, researchers looked at data from 5,124 participants aged 5 to 70 in the Framingham Heart Study
.
From 1971 to the present, these participants underwent longitudinal examinations on average every 4 years, for a total of 10
.
At each exam and at three age groups (35-50, 51-60, 61-70) in adulthood, the researchers assessed Alzheimer's disease with multiple known risk factors for cardiovascular disease and diabetes ( Includes links between good cholesterol (HDL-C), bad cholesterol (LDL-C), triglycerides, glucose, blood pressure, smoking, and body mass index)
.
They found that good cholesterol (HDL-C) levels in early (35-50 years) and mid-adulthood (51-60 years) could be a predictor of Alzheimer's disease
.
Specifically, each 15 mg/dL increase in good cholesterol (HDL-C) reduced Alzheimer's risk by 15.
4% and 17.
9% in the early and mid-adult groups, respectively
.
When adjusting for dyslipidemia treatment, the association remained significant in the mid-adulthood group.
In addition, blood glucose levels in mid-adulthood were significantly associated with Alzheimer's disease, with an effect of almost the same magnitude as good cholesterol levels, that is, for every 15 mg/dL increase , the risk of Alzheimer's increased by 14.
5%
.
(Note: normal fasting blood glucose is 70-110mg/dL) The above findings are the first to show that cardiovascular disease risk factors, including good cholesterol (HDL-C) levels, have not been considered a strong risk for Alzheimer's disease Factors, in fact, as early as age 35, these factors begin to contribute to the future development of Alzheimer's disease
.
Therefore, these factors should be carefully managed from early adulthood, with effective interventions to reduce the risk of cardiovascular disease, diabetes and Alzheimer's disease to maximize healthy living in later life, the researchers said
.
Paper link: https://doi.
org/10.
1002/alz.
12641https://science.
sciencemag.
org/content/373/6556/808
