Long-distance transport of growth hormone plays an important role in the feedback of side-grown organs on stem stem cells.

Stem cells are the source of organs, but can organs respond to regulate stem cells? Feedback from differentiated cells on stem cells helps to dynamically maintain the steady state of stem cells, adapting the number and activity of stem cells to endogenous changes.
animals, differentiated cells are fed back into stem cells by secreting diffused signal molecules.
plants, is there feedback regulation, how to achieve feedback regulation at the molecular level? The Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and Zhang Lei of the International Mathematics Research Center of Peking University have found that long-distance transport of growth hormone plays an important role in the feedback of side-grown organs on stem stem cells.
studies have found that the growth hormone content in stem stem cell region is negatively regulated stem cell balance, and the high growth hormone content leads to accelerated stem cell differentiation.
calculation simulation shows that the growth hormone transported from the progenitor base of the side-living organ can inhibit the growth hormone of the stem tip, thus maintaining the steady state of the stem cell growth hormone concentration.
genetic analysis and microsurgery experiments verified the model conclusions, found that in the leaves, flower base dysplasia mutants or after the removal of the original base, stem stem cell region growth hormone transport strengthened, growth hormone concentration decreased, stem stem cells increased.
growing stem cell clusters to produce more lateral organs.
the model explains the increase in stem stem cell regions in side-grown organ mutants, especially periodicly changing phenotypes.
the study reveals that the maintenance of plant stem cells in a stable state is different from that of animal stem cells at the molecular level. The findings were published on January 22,
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research has been supported by the National Natural Science Foundation of China, the National Key Basic Research and Development Program (973 Plan), the "People's Plan" of the Central Group Department and the National Key Laboratory of Plant Genomics.
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