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    Home > Active Ingredient News > Endocrine System > "Low-calorie diet" may help diabetics "get rid of" antihypertensive drugs!

    "Low-calorie diet" may help diabetics "get rid of" antihypertensive drugs!

    • Last Update: 2021-06-30
    • Source: Internet
    • Author: User
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    .

    Introduction: For every kilogram of weight loss, systolic blood pressure is reduced by 0.
    53mmHg, and diastolic blood pressure is reduced by 0.
    34mmHg.
    .
    .
    Recently, a post-analysis of DiRECT research data was published in Diabetologia magazine, and the study found that low-calorie diet induces weight Relief can significantly reduce the blood pressure level of adult type 2 diabetes (T2DM) patients, and it may even be possible to completely get rid of antihypertensive drugs.
    The side effect is that it may increase the symptoms of mild dizziness
    .

    Study description The DiRECT study is an open, randomized trial conducted in 49 primary care centers in Scotland and Tyneside, England, to evaluate whether effective weight management in primary care centers can achieve sustained T2DM remission
    .

    The results showed that compared with the control group, the low-carb diet intervention group lost more weight and had a higher diabetes remission rate
    .

     (Image source: Fei Tang Xin Dong) This study is a re-analysis of DiRECT trial data.
    Researchers analyzed blood pressure changes, changes in antihypertensive drug prescriptions, and other symptoms of 143 participants in the intervention group (including 79 males).
    Names), and data on a subset of patients (n=69) who discontinued antihypertensive drugs at the beginning of a complete diet replacement
    .

    In this cohort, 81 participants were diagnosed with hypertension, and 78 (55%) participants received antihypertensive medication at baseline
    .

     In order to prevent the occurrence of orthostatic hypotension, patients who have previously used antihypertensive drugs are required to stop antihypertensive drugs (except beta blockers for other treatment purposes), and then decide whether to reactivate antihypertensive drugs based on the blood pressure during follow-up.
    Compress the drug (using the established drug restart plan)
    .

    Among the 78 participants who had previously taken antihypertensive drugs, 65 (83%) completely stopped antihypertensive drugs, and 4 (5%) stopped some of them
    .

     Low-carb diet brings significant reduction in blood pressure.
    Researchers found that the overall average blood pressure level of participants decreased significantly from the beginning of the full diet replacement (week 1), and decreased significantly at the 20th week, 12 months and 24 months
    .

    The researchers wrote that for participants at baseline no history of hypertension, decreased blood pressure is "immediate and quite significant"
    .

     However, the average blood pressure of the 69 participants who were asked to stop antihypertensive drugs at the time of enrollment did not have a significant decrease in the first week, but a significant decrease from the 9th week (the average decrease in systolic blood pressure: -4.
    5mmHg, P=0.
    03, the average decrease in tension pressure: -2.
    5mmHg, P=0.
    03).
    In the follow-up study, about two-thirds of the antihypertensive drugs were reactivated, and 19 (28%) remained stopped at 24 months.
    Medicine status
    .

     Also, it is worth noting that of the 53 participants who achieved sustained remission of type 2 diabetes (average weight loss of 11.
    4 kg) at 24 months, 31 had received treatment for hypertension
    .

     The core of blood pressure reduction lies in two words-weight loss.
    In the mixed effects regression model, researchers found that weight change is an important predictor of blood pressure changes: for every kilogram of weight loss: systolic blood pressure is reduced by 0.
    53mmHg, diastolic blood pressure is reduced by 0.
    34 mmHg
    .

    (P value <0.
    0001) Figure 1 The average change in body weight during the complete diet replacement period in the entire intervention group (n=143) and the antihypertensive drug group (n=69).
    Note: AH, antihypertensive drugs Figure 2 All In terms of side effects of changes in systolic blood pressure (mmHg) during continuous TDR, all subjects who discontinued antihypertensive drugs and one or more antihypertensive drugs without a history of hypertension, 51 subjects reported mild Moderate to moderate dizziness, suggesting orthostatic hypotension
    .

     Research suggests that this research shows that it is safe and effective to reduce blood pressure in type 2 diabetic patients through a low-carbon diet (the core is weight loss), and even to get rid of "antihypertensive drugs", but do not ignore regular blood pressure monitoring, especially Patients who have taken ≥2 types of antihypertensive drugs in the past, because more than two-thirds of patients may need to re-use the drugs in the future
    .

     Reference: Leslie WS, et al.
    Diabetologia.
    2021; doi:10.
    1007/s00125-021-05471.
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