-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Scientists from the University of Pittsburgh School of Medicine and the University of Wisconsin-Madison reported in the journal Science Translational Medicine that a combination of targeted radiopharmaceutical therapy and immunotherapy can significantly promote the eradication of metastatic cancer in mice, even if the radiation dose is too high.
"We are very excited-such a low dose of radiation, we did not expect the response to be so positive," said lead author Ravi Patel, MD, an assistant professor at Pete and a radiation oncologist at UPMC Hillman Cancer Center
By helping the patient's immune system fight cancer, immunotherapy has revolutionized cancer treatment
In these cases, oncologists have discovered that external radiation therapy (EBRT)-placing patients in a carefully calibrated machine and directing a beam of radiation directly at their tumor-can help reduce the "cold" or "resistant" "" tumors are transformed into "hot" tumors.
EBRT usually cannot be transferred to all tumor sites in patients whose cancer has metastasized or spread to other parts of the body, because distant tumors may be too small, too large, and spread, and the patient cannot tolerate so much radiation
Patel and senior author Zachary Morris, MD, associate professor of human oncology at the University of Wisconsin School of Medicine and Public Health, and their colleagues designed a study to treat mice with immunological cold metastatic cancer in addition to immunotherapy.
"Because the radiation from the target radionuclide therapy, if the dose is too high or at the wrong time, it may kill or destroy tumor-infiltrating immune cells, and we ultimately want to destroy these tumors.
To this end, Patel and Morris worked closely with a team of medical physicists led by Dr.
To their surprise, those mice that took too low a dose alone to kill cancer were cured of these cancers when they were taken with immunotherapy
Patel said that low-dose radiation did not destroy the tumor, but "stressed the tumor cells" and stimulated the immune system's typical response to infection
In addition, when the tumor cells were reintroduced into mice cured by the combination therapy, they quickly repelled these cells and no longer developed cancer
Patel said: "The use of low-dose radiotherapy and immunotherapy to eradicate their cancer, it also acts as an anti-cancer vaccine to prevent mice from getting this cancer again
In addition to research on mice, these internal medicine scientists also collaborated with David Vail, a veterinarian at the University of Wisconsin School of Veterinary Medicine, to try to combine targeted radionuclide therapy and immunity Therapies are combined to treat pet dogs with naturally occurring metastatic cancer
In these two animal studies, the researchers used a new type of drug that can target almost any type of cancer, including tumors in any part of the body
.
The preparation was developed by one of the co-authors, Dr.
Jamey Weichert, Professor of Radiology at the University of Wisconsin School of Medicine and Public Health, and Dr.
Reinier Hernandez, Assistant Professor of Medical Physics at the University of Wisconsin-Madison
.
A start-up company headquartered in Madison, Archeus Technologies, is currently completing research to apply for approval from the U.
S.
Food and Drug Administration (fda) to begin testing the drug in human clinical trials
.
Patel said: "In order to develop our findings into a new standard of care, human clinical trials are also needed
.
" "At the same time, the concept of this method can now be tested on humans, using approved types for specific types.
Radiation therapy for cancer
.
"