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The Zika virus (ZIKV), a genus of the yellow fever virus, was first discovered in Africa in the 1940s and is the main vector of the Aedes aegypti mosquito, which is more infectious to humans, especially those with low immunity.
pregnant women infected with the Zika virus can cause microcephaly or even death in newborns.
since May 2015, the Zika virus epidemic has spread widely in Latin America and spread to more than 60 countries, raising the alarm of an international public health emergency.
blood-sucking arthropods inhibit host immunity and clotting reactions through their salivary gland active ingredients in order to obtain a blood meal successfully from the host.
mosquitoes as a widely distributed blood-sucking arthropods and the first major pathogen vector animals, its transmission of a variety of pathogens mechanism is not clear.
the Kunming Institute of Zoology of the Chinese Academy of Sciences, together with Tsinghua University, the Institute of Biophysics of the Chinese Academy of Sciences, the Institute of Parasitic Disease prevention and control in Yunnan Province, the Chinese of the PlaA Academy of Military Medical Sciences and other scientific research units, isolated from the salivary glands of the Aedes aegypti mosquito to obtain a molecular weight of 15 kDa immunosuppressant toxin protein (named LTRIN), and to explore the biochemical characteristics and physiological activity of the protein.
study found that the expression of LTRIN increased significantly during blood-sucking.
LTRIN assists in the spread of Zika virus by inhibiting the lymphocytoxbeta-beta receptor signaling pathway, causing low levels of immunity at the host's blood-sucking site.
antibodies against LTRIN can suppress Zika virus infection mediated by the Aedes aegypti mosquito.
the study: (1) explored the environmental adaptation mechanism of the successful blood-sucking of the Aedes aegypti mosquito; (2) identified the new immunosuppressant candidate drug molecules; (3) studied the mechanism of insect-borne pathogen transmission; and (4) demonstrated that lyhoctoxin receptor interventions play an important role in controlling the spread of the Zika virus. On March 5,
, the results of the study were published online in the journal Nature Logic, using the results of the Salivary factor RIN from Aedes aegypti frees zika virus transmission bying with the lymphotoxin-beta-geter.
, Kunming Animal Institute postdoctoral student Yu Lin, doctoral student Guo Xiaomin, assistant researcher Shen Chuanbin, assistant researcher Yu Xue and Tsinghua University master's student Sun Peng are co-first authors of the article, Kunming Animal Institute researcher Lai Wei, Qi Xiaopeng and Tsinghua University researcher Cheng Gong as co-authors of the article.
research work has been supported by the Ministry of Science and Technology's key research and development program, the National Natural Science Foundation of China, the Chinese Academy of Sciences and the Yunnan Provincial Science and Technology Department.
papers have received attention and coverage from BioCentury Innovations.
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